Proteins of the intermediate filament (IF) supergene family are ubiquitous structural
components that comprise, in a cell type–specific manner, the cytoskeleton proper in animal …

Keratins are the intermediate filament (IF)-forming proteins of epithelial cells. Since their
initial characterization almost 30 years ago, the total number of mammalian keratins has …

▪ Abstract The superfamily of intermediate filament (IF) proteins contains at least 65 distinct
proteins in man, which all assemble into∼ 10 nm wide filaments and are principal structural …

Intermediate filaments (IFs) are key players in multiple cellular processes throughout human
tissues. Their biochemical and structural properties are important for understanding filament …

We have investigated the functional role of the non-helical end domains of vimentin on its
assembly properties using truncated Xenopus and human recombinant proteins. Removal of …

A major cytoskeletal polypeptide (Mr approximately 46,000; protein IT) of human intestinal
epithelium was characterized by biochemical and immunological methods. The polypeptide …

Keratins are obligate heterodimer proteins that form the intermediate filament cytoskeleton of
all epithelial cells. Keratins are tissue and differentiation specific and are expressed in pairs …

From the hairs on our head to the soles of our feet, our bodies are composed of cells rich in
intracellular fibrous proteins called intermediate filaments (IF). Immunological and …

Cytokeratins are a large multigene family comprising two polypeptide types, ie acidic (type I)
and basic (type II) ones, which are distinguished on the basis of immunological, peptide …

Because of extraordinarily tight coiled-coil associations of type I and type II keratins, the
composition and structure of keratin subunits has been difficult to determine. We report here …