DNA–protein crosslinks and their resolution
P Weickert, J Stingele - Annual Review of Biochemistry, 2022 - annualreviews.org
Covalent DNA–protein crosslinks (DPCs) are pervasive DNA lesions that interfere with
essential chromatin processes such as transcription or replication. This review strives to …
essential chromatin processes such as transcription or replication. This review strives to …
Mechanisms of DNA–protein crosslink repair
Covalent DNA–protein crosslinks (DPCs, also known as protein adducts) of topoisomerases
and other proteins with DNA are highly toxic DNA lesions. Of note, chemical agents that …
and other proteins with DNA are highly toxic DNA lesions. Of note, chemical agents that …
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair
Y Oka, Y Nakazawa, M Shimada, T Ogi - Nature Cell Biology, 2024 - nature.com
DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and
transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes …
transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes …
Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN
Covalent DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with essential
chromatin transactions, such as replication and transcription. Little was known about DPC …
chromatin transactions, such as replication and transcription. Little was known about DPC …
Maintaining genome stability at the replication fork
D Branzei, M Foiani - Nature reviews Molecular cell biology, 2010 - nature.com
Aberrant DNA replication is a major source of the mutations and chromosome
rearrangements that are associated with pathological disorders. When replication is …
rearrangements that are associated with pathological disorders. When replication is …
Replication-coupled DNA-protein crosslink repair by SPRTN and the proteasome in Xenopus egg extracts
NB Larsen, AO Gao, JL Sparks, I Gallina, RA Wu… - Molecular cell, 2019 - cell.com
DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and
therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in …
therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in …
Repair of a DNA-protein crosslink by replication-coupled proteolysis
DNA-protein crosslinks (DPCs) are caused by environmental, endogenous, and
chemotherapeutic agents and pose a severe threat to genome stability. We use Xenopus …
chemotherapeutic agents and pose a severe threat to genome stability. We use Xenopus …
DNA–protein crosslink proteases in genome stability
A Ruggiano, K Ramadan - Communications Biology, 2021 - nature.com
Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …
Ubiquitin signaling and the proteasome drive human DNA–protein crosslink repair
M Essawy, L Chesner, D Alshareef, S Ji… - Nucleic acids …, 2023 - academic.oup.com
DNA–protein crosslinks (DPCs) are large cytotoxic DNA lesions that form following exposure
to chemotherapeutic drugs and environmental chemicals. Nucleotide excision repair (NER) …
to chemotherapeutic drugs and environmental chemicals. Nucleotide excision repair (NER) …
Isolation and detection of DNA–protein crosslinks in mammalian cells
I Torrecilla, A Ruggiano, K Kiianitsa… - Nucleic Acids …, 2024 - academic.oup.com
DNA–protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …