Oestrogen receptor-α (ERα), a key driver of breast cancer, normally requires oestrogen for
activation. Mutations that constitutively activate ERα without the need for hormone binding …

The link between estrogen and the development and proliferation of breast cancer is well
documented. Estrogen stimulates growth and inhibits apoptosis through estrogen receptor …

On Thursday, January2, 1997, Dr. HerbertSoule, the scientist who developed the MCF-7
breast cancer cell line, died. At the time, we were in the process of writingthis tributeto …

In light of the current outbreak of Ebola virus disease, there is an urgent need to develop
effective therapeutics to treat Ebola infection, and drug repurposing screening is a …

Identification of a new isoform of the human estrogen receptor‐alpha (hER‐α) that is encoded
by distinct transcripts and that is able to repress hER‐α activation function 1 | The EMBO Journal …

Since cell proliferation is indispensable for the growth and development of the breast, and
estrogens are considered to play a major role in promoting cell proliferation, while …

MicroRNAs (miRNAs), single-stranded non-coding RNAs, influence myriad biological
processes that can contribute to cancer. Although tumor-suppressive and oncogenic …

Estrogen is essential for normal growth and differentiation in the mammary gland. It also
supports growth of approximately 50% of primary breast cancers. For this reason, removal of …

The human estrogen receptor α (ER α) has been tagged at its amino terminus with the S65T
variant of the green fluorescent protein (GFP), allowing subcellular trafficking and …

Advanced hormone-independent prostate cancer is characterized by a significant loss of
androgen receptor (AR) expression in 20–30% of the tumors. The transcriptional block …