Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

Idiopathic pulmonary fibrosis (IPF) is a progressive, and ultimately fatal, chronic interstitial
lung disease characterized by enhanced extracellular matrix deposition. Repetitive alveolar …

Aging promotes lung function decline and susceptibility to chronic lung diseases, which are
the third leading cause of death worldwide. Here, we use single cell transcriptomics and …

The extracellular matrix (ECM) is a complex assembly of hundreds of proteins forming the
architectural scaffold of multicellular organisms. In addition to its structural role, the ECM …

The lung's unique extracellular matrix (ECM), while providing structural support for cells, is
critical in the regulation of developmental organogenesis, homeostasis and injury-repair …

The correspondence of cell state changes in diseased organs to peripheral protein
signatures is currently unknown. Here, we generated and integrated single‐cell …

Transcytosis of polymeric IgA and IgM from the basolateral surface to the apical side of the
epithelium and subsequent secretion into mucosal fluids are mediated by the polymeric …

Osteosarcoma (OS), which occurs most commonly in adolescents, is associated with a high
degree of malignancy and poor prognosis. In order to develop an accurate treatment for OS …

The extracellular matrix (ECM) is a complex assembly of hundreds of proteins that
constitutes the scaffold of multicellular organisms. In addition to providing architectural and …

The pathogenesis of pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF) and
other forms of interstitial lung disease, involves a complex interplay of various factors …