The clinical syndromes comprising urinary tract infection (UTI) continue to exert significant
impact on millions of patients worldwide, most of whom are otherwise healthy women …

As the key components of innate immunity, human host defense antimicrobial peptides and
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …

Diverse commensal populations are now regarded as key to physiological homeostasis and
protection against disease. Although bacteria are the most abundant component of …

The bladder is continuously protected by passive defences such as a mucus layer,
antimicrobial peptides and secretory immunoglobulins; however, these defences are …

Diabetes is known to increase susceptibility to infections, partly due to impaired granulocyte
function and changes in the innate immunity. Here, we investigate the effect of diabetes, and …

BACKGROUND Reproductive tract infection is an important factor leading to male and
female infertility. Among female infertility factors, microbial and viral infections are the main …

Urinary tract infections (UTIs) are among the most common bacterial infections seen in
clinical practice. The ascent of UTI-causing pathogens to the kidneys results in …

The discovery of microbial communities in the urinary tract (the urobiome) has fundamentally
altered the previous doctrine regarding urine sterility and associated urinary disorders …

The increasing antibiotic resistance among uropathogenic bacteria warrants alternative
therapeutic strategies. We demonstrate the potential of the synthetic peptide CD4-PP …

Second-and third-line treatments of patients with antibiotic-resistant infections can have
serious side effects, such as organ failure with prolonged care and recovery. As clinical …