Immune therapy of cancer is a rapidly evolving field, with long-deserved successes now
finally achieved. As new pathways triggered by the immune synapsis are elucidated, and …

A large volume of data relevant to immunology research has accumulated due to
sequencing of genomes of the human and other model organisms. At the same time, huge …

We have developed novel DNA fusion vaccines encoding tumor Ags fused to pathogen-
derived sequences. This strategy activates linked T cell help and, using fragment C of tetnus …

Vaccination against target antigens expressed by cancer cells has now become a realistic
goal. DNA vaccines provide a direct link between identification of genetic markers in tumors …

DNA vaccination has been widely explored to develop new, alternative and efficient
vaccines for cancer immunotherapy. DNA vaccines offer several benefits such as specific …

Over the past few years, improved understanding of the molecular basis of interactions
between antigen presenting cells and effector cells and advances in informatics have both …

T cell receptors are antigen-specific proteins that have evolved to recognize peptide
antigens presented by human leukocyte antigen molecules on most cell types. Like …

AIM: To seek for an effective method to improve the immune responses induced by DNA
vaccine expressing HBV surface antigen (pCR3. 1-S) in Balb/c mice (H-2 d). METHODS …

Opinion statement T-cell non-Hodgkin's lymphoma (NHL) represents approximately 10% to
15% of all lympho-mas in Western countries. Patients with T-cell NHL are often treated …

Pertussis toxin (PT) is the major virulence factor of Bordetella pertussis, and detoxified PT is
a crucial antigen of acellular pertussis vaccine. Here, plasmid DNA expressing the pertussis …