Obstructive sleep apnoea heterogeneity and cardiovascular disease

S Redline, A Azarbarzin, Y Peker - Nature Reviews Cardiology, 2023 - nature.com
Obstructive sleep apnoea (OSA), characterized by recurrent periods of upper airway
obstruction and intermittent hypoxaemia, is prevalent in patients with cardiovascular disease …

Phenotypic approaches to obstructive sleep apnoea–new pathways for targeted therapy

DJ Eckert - Sleep medicine reviews, 2018 - Elsevier
People develop obstructive sleep apnoea (OSA) for different reasons. The ability to
understand these reasons, easily identify them in individual patients, and develop therapies …

Phenotypes in obstructive sleep apnea: a definition, examples and evolution of approaches

AV Zinchuk, MJ Gentry, J Concato, HK Yaggi - Sleep medicine reviews, 2017 - Elsevier
Obstructive sleep apnea (OSA) is a complex and heterogeneous disorder and the apnea
hypopnea index alone can not capture the diverse spectrum of the condition. Enhanced …

Personalized management approach for OSA

JC Carberry, J Amatoury, DJ Eckert - Chest, 2018 - Elsevier
OSA is a heterogeneous disorder. If left untreated, it has major health, safety, and economic
consequences. In addition to varying levels of impairment in pharyngeal anatomy …

Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea

AV Zinchuk, S Jeon, BB Koo, X Yan, DM Bravata, L Qin… - Thorax, 2018 - thorax.bmj.com
Background Obstructive sleep apnoea (OSA) is a heterogeneous disorder, and improved
understanding of physiologic phenotypes and their clinical implications is needed. We …

More than the sum of the respiratory events: personalized medicine approaches for obstructive sleep apnea

BA Edwards, S Redline, SA Sands… - American journal of …, 2019 - atsjournals.org
Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined
by the apnea–hypopnea index (AHI). Continuous positive airway pressure is generally first …

Quantifying the arousal threshold using polysomnography in obstructive sleep apnea

SA Sands, PI Terrill, BA Edwards… - Sleep, 2018 - academic.oup.com
Abstract Study Objectives Precision medicine for obstructive sleep apnea (OSA) requires
noninvasive estimates of each patient's pathophysiological “traits.” Here, we provide the first …

Upper airway collapsibility (Pcrit) and pharyngeal dilator muscle activity are sleep stage dependent

JC Carberry, AS Jordan, DP White, A Wellman… - Sleep, 2016 - academic.oup.com
Abstract Study Objectives: An anatomically narrow/highly collapsible upper airway is the
main cause of obstructive sleep apnea (OSA). Upper airway muscle activity contributes to …

Clinical phenotypes and comorbidity in European sleep apnoea patients

T Saaresranta, J Hedner, MR Bonsignore, RL Riha… - PloS one, 2016 - journals.plos.org
Background Clinical presentation phenotypes of obstructive sleep apnoea (OSA) and their
association with comorbidity as well as impact on adherence to continuous positive airway …

Obstructive sleep apnea without obesity is common and difficult to treat: evidence for a distinct pathophysiological phenotype

EL Gray, DK McKenzie, DJ Eckert - Journal of Clinical Sleep …, 2017 - jcsm.aasm.org
Study Objectives: To determine the proportion and physiological characteristics of nonobese
patients with obstructive sleep apnea (OSA) and their response to prescribed therapy …