A comprehensive overview of globally approved JAK inhibitors
Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes
four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling …
four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling …
JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …
Targeting the Janus kinase family in autoimmune skin diseases
Autoimmune skin diseases are characterized by significant local and systemic inflammation
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …
Physiology and pathophysiology of itch
F Cevikbas, EA Lerner - Physiological reviews, 2020 - journals.physiology.org
Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly
understood and appreciated. The pathophysiological consequences of itch impact quality of …
understood and appreciated. The pathophysiological consequences of itch impact quality of …
JAKs and STATs from a clinical perspective: loss-of-function mutations, gain-of-function mutations, and their multidimensional consequences
N Ott, L Faletti, M Heeg, V Andreani… - Journal of clinical …, 2023 - Springer
The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …
Tyrosine kinases in autoimmune and inflammatory skin diseases
Tyrosine kinases relay signals from diverse leukocyte antigen receptors, innate immune
receptors, and cytokine receptors, and therefore mediate the recruitment and activation of …
receptors, and cytokine receptors, and therefore mediate the recruitment and activation of …
Metformin inhibits melanoma cell metastasis by suppressing the miR-5100/SPINK5/STAT3 axis
D Suwei, X Yanbin, W Jianqiang, M Xiang… - Cellular & Molecular …, 2022 - Springer
Melanoma is the most lethal skin cancer characterized by its high metastatic potential. It is
urgent to find novel therapy strategies to overcome this feature. Metformin has been …
urgent to find novel therapy strategies to overcome this feature. Metformin has been …
Alginate/gelatin encapsulation promotes NK cells differentiation potential of bone marrow resident C-kit+ hematopoietic stem cells
The ability of natural killer (NK) cells to destroy cancerous cells with no prior sensitization
has made them attractive candidates for cell therapy. The application of hydrogels must be …
has made them attractive candidates for cell therapy. The application of hydrogels must be …
JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome
KL Del Bel, RJ Ragotte, A Saferali, S Lee… - Journal of Allergy and …, 2017 - jacionline.org
FIG 2. A, The median Treact in relation to the challenge dose. B, The median Swheal in
relation to the challenge dose. Both graphs (box plots) display the distribution of the data as …
relation to the challenge dose. Both graphs (box plots) display the distribution of the data as …
Research techniques made simple: mouse models of atopic dermatitis
D Kim, T Kobayashi, K Nagao - Journal of Investigative Dermatology, 2019 - Elsevier
Atopic dermatitis (AD) is a common, chronic inflammatory skin disease characterized by
impaired barrier function, eczematous dermatitis, and chronic pruritus. Mouse models have …
impaired barrier function, eczematous dermatitis, and chronic pruritus. Mouse models have …