Lung ventilation fluctuates widely with behavior but arterial PCO 2 remains stable. Under
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …

We review the substantial recent progress made in understanding the underlying
mechanisms controlling breathing and the applicability of these findings to selected human …

Twenty‐five years ago, a new physiological preparation called the working heart–brainstem
preparation (WHBP) was introduced with the claim it would provide a new platform allowing …

Key points Central chemoreceptor stimulation, by hypercapnia (acidosis), and peripheral, by
hypoxia plus hypercapnia, evoke reflex increases in ventilation and sympathetic outflow …

During sojourn to high altitudes, progressive time-dependent increases occur in ventilation
and in sympathetic nerve activity over several days, and these increases persist upon acute …

Key Points The influence of specific carotid body (CB) normoxic hypocapnia, hypercapnia
and normocapnia on the ventilatory sensitivity of central chemoreceptors to systemic …

We have examined the importance of three long‐standing questions concerning
chemoreceptor influences on cardiorespiratory function which are currently experiencing a …

The retrotrapezoid nucleus (RTN) regulates breathing in a CO2‐and state‐dependent
manner. RTN neurons are glutamatergic and innervate principally the respiratory pattern …

Mild intermittent hypoxia initiates progressive augmentation (PA) and ventilatory long‐term
facilitation (vLTF) in humans. The magnitude of these forms of plasticity might be influenced …

How central and peripheral chemoreceptor drives to breathe interact in humans remains
contentious. We measured the peripheral chemoreflex sensitivity to hypoxia (PChS) at …