[HTML][HTML] Regulation of breathing and autonomic outflows by chemoreceptors
PG Guyenet - Comprehensive Physiology, 2014 - ncbi.nlm.nih.gov
Lung ventilation fluctuates widely with behavior but arterial PCO 2 remains stable. Under
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …
Pathophysiology of human ventilatory control
JA Dempsey, CA Smith - European Respiratory Journal, 2014 - Eur Respiratory Soc
We review the substantial recent progress made in understanding the underlying
mechanisms controlling breathing and the applicability of these findings to selected human …
mechanisms controlling breathing and the applicability of these findings to selected human …
Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years
Twenty‐five years ago, a new physiological preparation called the working heart–brainstem
preparation (WHBP) was introduced with the claim it would provide a new platform allowing …
preparation (WHBP) was introduced with the claim it would provide a new platform allowing …
Simultaneous assessment of central and peripheral chemoreflex regulation of muscle sympathetic nerve activity and ventilation in healthy young men
Key points Central chemoreceptor stimulation, by hypercapnia (acidosis), and peripheral, by
hypoxia plus hypercapnia, evoke reflex increases in ventilation and sympathetic outflow …
hypoxia plus hypercapnia, evoke reflex increases in ventilation and sympathetic outflow …
Role of chemoreception in cardiorespiratory acclimatization to, and deacclimatization from, hypoxia
JA Dempsey, FL Powell, GE Bisgard… - Journal of Applied …, 2014 - journals.physiology.org
During sojourn to high altitudes, progressive time-dependent increases occur in ventilation
and in sympathetic nerve activity over several days, and these increases persist upon acute …
and in sympathetic nerve activity over several days, and these increases persist upon acute …
Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO2: role of carotid body CO2
CA Smith, GM Blain, KS Henderson… - The Journal of …, 2015 - Wiley Online Library
Key Points The influence of specific carotid body (CB) normoxic hypocapnia, hypercapnia
and normocapnia on the ventilatory sensitivity of central chemoreceptors to systemic …
and normocapnia on the ventilatory sensitivity of central chemoreceptors to systemic …
Rethinking O2, CO2 and breathing during wakefulness and sleep
JA Dempsey, TD Gibbons - The Journal of Physiology, 2023 - Wiley Online Library
We have examined the importance of three long‐standing questions concerning
chemoreceptor influences on cardiorespiratory function which are currently experiencing a …
chemoreceptor influences on cardiorespiratory function which are currently experiencing a …
Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus
PG Guyenet, DA Bayliss, RL Stornetta… - The Journal of …, 2018 - Wiley Online Library
The retrotrapezoid nucleus (RTN) regulates breathing in a CO2‐and state‐dependent
manner. RTN neurons are glutamatergic and innervate principally the respiratory pattern …
manner. RTN neurons are glutamatergic and innervate principally the respiratory pattern …
The hypoxic ventilatory response and hypoxic burden are predictors of the magnitude of ventilatory long‐term facilitation in humans
GS Panza, DM Kissane, S Puri… - The Journal of …, 2023 - Wiley Online Library
Mild intermittent hypoxia initiates progressive augmentation (PA) and ventilatory long‐term
facilitation (vLTF) in humans. The magnitude of these forms of plasticity might be influenced …
facilitation (vLTF) in humans. The magnitude of these forms of plasticity might be influenced …
A test of the interaction between central and peripheral respiratory chemoreflexes in humans
NA Guluzade, JD Huggard, J Duffin… - The Journal of …, 2023 - Wiley Online Library
How central and peripheral chemoreceptor drives to breathe interact in humans remains
contentious. We measured the peripheral chemoreflex sensitivity to hypoxia (PChS) at …
contentious. We measured the peripheral chemoreflex sensitivity to hypoxia (PChS) at …