Significance: Oxidative stress is considered to be an important component of various
diseases. A vast number of methods have been developed and used in virtually all diseases …

This article looks back to the antioxidant/free radical field in 1994 and discusses how it has
progressed in the past 18 years. In some areas, there has been little change: the role of …

Chronic psychological stress appears to accelerate biological aging, and oxidative damage
is an important potential mediator of this process. However, the mechanisms by which …

Type 2 diabetes (T2DM) and its complications constitute a major worldwide public health
problem, with high rates of morbidity and mortality. Biomarkers for predicting the occurrence …

The term 'antioxidant paradox'is often used to refer to the observation that oxygen radicals
and other reactive oxygen species are involved in several human diseases, but giving large …

Oxidatively generated damage to DNA has been implicated in the pathogenesis of a wide
variety of diseases. Increasingly, interest is also focusing upon the effects of damage to the …

The past decade has provided exciting insights into a novel class of central (small) RNA
molecules intimately involved in gene regulation. Only a small percentage of our DNA is …

An age-associated increase in oxidative damage to nucleic acids, predominantly to RNA,
has been recently demonstrated in neurons of human and rodent brains, which may play a …

Background DNA and RNA oxidations have been linked to diseases such as cancer,
arteriosclerosis, neurodegeneration and diabetes. The prototype base modification studied …

Aims The possible link between hyperglycaemia-induced oxidative stress (OxS) and
diabetic complications is suggested by many in vitro studies. However, not much attention …