African countries face key challenges in the deployment of GM crops due to incongruities in
the processes for effective and efficient commercial release while simultaneously ensuring …

Purpose The 2015 American College of Medical Genetics and Genomics–Association for
Molecular Pathology (ACMG–AMP) guidelines were a major step toward establishing a …

The majority of Lynch syndrome (LS), also known as hereditary non-polyposis colorectal
cancer (HNPCC), has been linked to heterozygous defects in DNA mismatch repair (MMR) …

Numerous unclassified variants (UVs) have been found in the mismatch repair genes MLH1
and MSH2 involved in hereditary nonpolyposis colorectal cancer (HNPCC or Lynch …

Background & Aims: Germline mutations in mismatch repair genes are associated with
hereditary nonpolyposis colorectal cancer. A significant proportion of mutations are …

The functional characterization of nonsynonymous single nucleotide polymorphisms in
human mismatch repair (MMR) genes has been critical to evaluate their pathogenicity for …

Mutations in DNA MMR genes, mainly MSH2 and MLH1, account for the majority of HNPCC,
an autosomal dominant predisposition to colorectal cancer and other malignancies. The …

Mismatch repair (MMR) gene sequence variants of uncertain clinical significance are often
identified in suspected L ynch syndrome families, and this constitutes a challenge for both …

Background: Germline mutations in DNA mismatch repair (MMR) genes cause Lynch
syndrome colon cancers. Less understood is the risk of colon cancer associated with …

Lynch syndrome (LS) is caused by germline mutations in DNA mismatch repair (MMR)
genes and is the most prevalent hereditary colorectal cancer syndrome. A significant …