Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence
indicates that the mitral valve is not a passive structure, but—even in adult life—remains …

Medulloblastoma is heterogeneous, being characterized by molecular subgroups that
demonstrate distinct gene expression profiles. Activation of the WNT or SHH signaling …

Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in
1975. Thirty five years of FLNa research has revealed its structure in great detail, discovered …

Cell motility is regulated by multiple processes, including cell protrusion, cell retraction, cell–
matrix adhesion, polarized exocytosis and polarized vesicle trafficking, each of which is …

Matrix and tissue rigidity guides many cellular processes, including the differentiation of
stem cells and the migration of cells in health and disease. Cells actively and transiently test …

Filamins (FLN) are large dimeric proteins that cross-link actin and work as important
scaffolds in human cells. FLNs consist of an N-terminal actin-binding domain followed by 24 …

Objectives: The purpose of this study was to assess the phenotype of Filamin C (FLNC)
truncating variants in dilated cardiomyopathy (DCM) and understand the mechanism …

The filamentous actin (F-actin) cytoskeleton is a composite material consisting of cortical
actin and bundled F-actin stress fibers, which together mediate the mechanical behaviors of …