Single‐molecule pull‐down (SiMPull) for new‐age biochemistry: Methodology and biochemical applications of single‐molecule pull‐down (SiMPull) for probing …
V Aggarwal, T Ha - BioEssays, 2014 - Wiley Online Library
Macromolecular interactions play a central role in many biological processes. Protein‐
protein interactions have mostly been studied by co‐immunoprecipitation, which cannot …
protein interactions have mostly been studied by co‐immunoprecipitation, which cannot …
[HTML][HTML] Cadherin clusters stabilized by a combination of specific and nonspecific cis-interactions
We demonstrate a combined experimental and computational approach for the quantitative
characterization of lateral interactions between membrane-associated proteins. In particular …
characterization of lateral interactions between membrane-associated proteins. In particular …
[HTML][HTML] General principles of binding between cell surface receptors and multi-specific ligands: A computational study
J Chen, SC Almo, Y Wu - PLoS computational biology, 2017 - journals.plos.org
The interactions between membrane receptors and extracellular ligands control cell-cell and
cell-substrate adhesion, and environmental responsiveness by representing the initial steps …
cell-substrate adhesion, and environmental responsiveness by representing the initial steps …
[HTML][HTML] 力敏感受体介导细胞功能调控的力学生物学研究
张欢， 赵国清， 冯锦腾， 林敏 - 力学进展, 2023 - lxjz.cstam.org.cn
细胞膜是细胞与外部环境进行物质与能量交换的界面, 是调节细胞正常生命活动的重要结构基础
. 细胞膜上力敏感受体可通过力学作用方式参与并影响细胞的力信号转导等功能 …
. 细胞膜上力敏感受体可通过力学作用方式参与并影响细胞的力信号转导等功能 …
On the formation of ordered protein assemblies in cell–cell interfaces
Crystal structures of many cell–cell adhesion receptors reveal the formation of linear
“molecular zippers” comprising an ordered one-dimensional array of proteins that form both …
“molecular zippers” comprising an ordered one-dimensional array of proteins that form both …
A multiscale and comparative model for receptor binding of 2019 novel coronavirus and the implication of its life cycle in host cells
The respiratory syndrome caused by a new type of coronavirus has been emerging from
China and caused more than one million death globally since December 2019. This new …
China and caused more than one million death globally since December 2019. This new …
[HTML][HTML] A computational model for kinetic studies of cadherin binding and clustering
Cadherin is a cell-surface transmembrane receptor that mediates calcium-dependent cell-
cell adhesion and is a major component of adhesive junctions. The formation of intercellular …
cell adhesion and is a major component of adhesive junctions. The formation of intercellular …
[HTML][HTML] Understanding the functional role of membrane confinements in TNF-mediated signaling by multiscale simulations
The interaction between TNFα and TNFR1 is essential in maintaining tissue development
and immune responses. While TNFR1 is a cell surface receptor, TNFα exists in both soluble …
and immune responses. While TNFR1 is a cell surface receptor, TNFα exists in both soluble …
[HTML][HTML] Ligand's Partition to the Lipid Bilayer Should Be Accounted for When Estimating Their Affinity to Proteins
MJ Moreno, A Salvador - Molecules, 2023 - mdpi.com
Ligand-protein interactions are usually studied in complex media that also contain lipids.
This is particularly relevant for membrane proteins that are always associated with lipid …
This is particularly relevant for membrane proteins that are always associated with lipid …
[HTML][HTML] Predicting protein–protein association rates using coarse-grained simulation and machine learning
Protein–protein interactions dominate all major biological processes in living cells. We have
developed a new Monte Carlo-based simulation algorithm to study the kinetic process of …
developed a new Monte Carlo-based simulation algorithm to study the kinetic process of …