Mechanisms of clathrin-mediated endocytosis

M Kaksonen, A Roux - Nature reviews Molecular cell biology, 2018 - nature.com
Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide
range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis …

Regulation of clathrin-mediated endocytosis

M Mettlen, PH Chen, S Srinivasan… - Annual review of …, 2018 - annualreviews.org
Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It
is responsible for the uptake of transmembrane receptors and transporters, for remodeling …

A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis

MJ Taylor, D Perrais, CJ Merrifield - PLoS biology, 2011 - journals.plos.org
Dual colour total internal reflection fluorescence microscopy is a powerful tool for decoding
the molecular dynamics of clathrin-mediated endocytosis (CME). Typically, the recruitment of …

Actin dynamics counteract membrane tension during clathrin-mediated endocytosis

S Boulant, C Kural, JC Zeeh, F Ubelmann… - Nature cell …, 2011 - nature.com
Clathrin-mediated endocytosis is independent of actin dynamics in many circumstances but
requires actin polymerization in others. We show that membrane tension determines the …

[HTML][HTML] Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition

L von Kleist, W Stahlschmidt, H Bulut, K Gromova… - Cell, 2011 - cell.com
Clathrin-mediated endocytosis (CME) regulates many cell physiological processes such as
the internalization of growth factors and receptors, entry of pathogens, and synaptic …

Endocytosis in the context-dependent regulation of individual and collective cell properties

S Sigismund, L Lanzetti, G Scita… - Nature Reviews Molecular …, 2021 - nature.com
Endocytosis allows cells to transport particles and molecules across the plasma membrane.
In addition, it is involved in the termination of signalling through receptor downmodulation …

[HTML][HTML] Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint

F Aguet, CN Antonescu, M Mettlen, SL Schmid… - Developmental cell, 2013 - cell.com
Numerous endocytic accessory proteins (EAPs) mediate assembly and maturation of
clathrin-coated pits (CCPs) into cargo-containing vesicles. Analysis of EAP function through …

Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin

L Meloty-Kapella, B Shergill, J Kuon, E Botvinick… - Developmental cell, 2012 - cell.com
Notch signaling induced by cell surface ligands is critical to development and maintenance
of many eukaryotic organisms. Notch and its ligands are integral membrane proteins that …

Insight into the role of clathrin‐mediated endocytosis inhibitors in SARS‐CoV‐2 infection

SS Alkafaas, AM Abdallah, S Ghosh… - Reviews in Medical …, 2023 - Wiley Online Library
Emergence of SARS‐CoV‐2 variants warrants sustainable efforts to upgrade both the
diagnostic and therapeutic protocols. Understanding the details of cellular and molecular …

Akt-ing up just about everywhere: compartment-specific Akt activation and function in receptor tyrosine kinase signaling

MG Sugiyama, GD Fairn, CN Antonescu - Frontiers in Cell and …, 2019 - frontiersin.org
The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …