WW domain-containing oxidoreductase: a candidate tumor suppressor
Common fragile site gene WWOX encodes a candidate tumor suppressor WW domain-
containing oxidoreductase. Alteration of this gene, along with dramatic downregulation of …
containing oxidoreductase. Alteration of this gene, along with dramatic downregulation of …
[HTML][HTML] WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies
WWOX was cloned as a putative tumor suppressor gene mapping to chromosomal fragile
site FRA16D. Deletions affecting WWOX accompanied by loss of expression are frequent in …
site FRA16D. Deletions affecting WWOX accompanied by loss of expression are frequent in …
Genome‐wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma
J Smida, H Xu, Y Zhang, D Baumhoer… - … journal of cancer, 2017 - Wiley Online Library
Osteosarcoma (OS) is the most common primary malignant bone tumor in children and
adolescents. It is characterized by highly complex karyotypes with structural and numerical …
adolescents. It is characterized by highly complex karyotypes with structural and numerical …
WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes …
NS Chang, J Doherty, A Ensign, L Schultz… - Journal of Biological …, 2005 - ASBMB
WW domain-containing oxidoreductase WOX1, also named WWOX or FOR, undergoes Tyr
33 phosphorylation at its first N-terminal WW domain and subsequent nuclear translocation …
33 phosphorylation at its first N-terminal WW domain and subsequent nuclear translocation …
Cancer-associated dysregulation of sumo regulators: Proteases and ligases
N Lara-Ureña, V Jafari… - International Journal of …, 2022 - mdpi.com
SUMOylation is a post-translational modification that has emerged in recent decades as a
mechanism involved in controlling diverse physiological processes and that is essential in …
mechanism involved in controlling diverse physiological processes and that is essential in …
WWOX in biological control and tumorigenesis
RI Aqeilan, CM Croce - Journal of cellular physiology, 2007 - Wiley Online Library
The WW domain‐containing oxidoreductase (WWOX) gene is located at 16q23. 1–16q23. 2,
a region that spans the second most common human fragile site, FRA16D. The WWOX …
a region that spans the second most common human fragile site, FRA16D. The WWOX …
Large common fragile site genes and cancer
DI Smith, S McAvoy, Y Zhu, DS Perez - Seminars in cancer biology, 2007 - Elsevier
The common fragile sites are large regions of genomic instability that are found in all
individuals and are hot spots for chromosomal rearrangements and deletions. A number of …
individuals and are hot spots for chromosomal rearrangements and deletions. A number of …
WWOX Gene Expression Abolishes Ovarian Cancer Tumorigenicity In vivo and Decreases Attachment to Fibronectin via Integrin α3
C Gourley, AJW Paige, KJ Taylor, C Ward, B Kuske… - Cancer research, 2009 - AACR
The WW domain–containing oxidoreductase (WWOX) gene is located at FRA16D, a
common fragile site involved in human cancer. Targeted deletion of Wwox in mice causes …
common fragile site involved in human cancer. Targeted deletion of Wwox in mice causes …
Common fragile sites: genomic hotspots of DNA damage and carcinogenesis
K Ma, L Qiu, K Mrasek, J Zhang, T Liehr… - International journal of …, 2012 - mdpi.com
Genomic instability, a hallmark of cancer, occurs preferentially at specific genomic regions
known as common fragile sites (CFSs). CFSs are evolutionarily conserved and late …
known as common fragile sites (CFSs). CFSs are evolutionarily conserved and late …
WWOX gene and gene product: tumor suppression through specific protein interactions
The WWOX gene, an archetypal fragile gene, encompasses a chromosomal fragile site at
16q23. 2, and encodes the approximately 46-kDa Wwox protein, with WW domains that …
16q23. 2, and encodes the approximately 46-kDa Wwox protein, with WW domains that …