Chronic pancreatitis (CP) is associated with a risk of pancreatic cancer and is characterized
by irreversible morphological changes, fibrosis, calcification, and exocrine and endocrine …

Abstract Background SPINK1 p. N34S gene variation is one of the endogenous factors
which seem to be associated with chronic pancreatitis (CP). However, in literature there is …

Introduction Cystic fibrosis transmembrane conductance regulator (CFTR) plays a central
role in pancreatic ductal fluid secretion by mediating Cl-and HCO3-ion transport across the …

Background. Environmental factors and genetic mutations have been increasingly
recognized as risk factors for chronic pancreatitis (CP). The PRSS1 p. R122H mutation was …

Materials and Methods: Idiopathic pancreatitis is defined as failure to detect risk factors
despite comprehensive clinical assessments. Next-generation sequencing and multiple …

Background Cystic fibrosis transmembrane conductance regulator IVS8-5T gene variation
appears to be associated with a higher risk of chronic pancreatitis (CP); however, there is …

Chronic pancreatitis (CP) is a progressive clinical picture that develops secondary to chronic
inflammation of the pancreas. Endocrine and exocrine insufficiency occurs in the later …

Several recent studies have reported associations between gene mutations and chronic
pancreatitis (CP); however, little is known about their association with risk of CP in the …

К основным генам предрасположенности к ХП относят PRSS1, SPINK1 и CFTR. Chang
(2014) выявил 16, 1% различных мутаций гена PRSS1 при аутоимунном панкреатите …

ABSTRACT Background: SPINK1 p. N34S gene variation is one of the endogenous factors
which seem to be associated with chronic pancreatitis (CP). However, in literature there is …