Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …

The definition of epigenetics refers that molecular modifications on DNA that can regulate
gene activity are independent of DNA sequence and mitotically stable. Notably, epigenetics …

To determine the dynamics of allelic-specific expression during mouse development, we
analyzed RNA-seq data from 23 F1 tissues from different developmental stages, including …

Circular RNAs (circRNAs) exhibit unique properties due to their covalently closed nature.
Models of circRNAs synthesis and function are emerging but much remains undefined about …

Genomic imprinting and X chromosome inactivation (XCI) require epigenetic mechanisms to
encode allele-specific expression, but how these specific tasks are accomplished at single …

In mammalian genomes, differentially methylated regions (DMRs) and histone marks
including trimethylation of histone 3 lysine 27 (H3K27me3) at imprinted genes are …

Long non-coding (lnc) RNAs are numerous and found throughout the mammalian genome,
and many are thought to be involved in the regulation of gene expression. However, the …

In mammalian genomes, a subset of genes is regulated by genomic imprinting, resulting in
silencing of one parental allele. Imprinting is essential for cerebral cortex development, but …

Background Allele-specific expression (ASE) refers to the preferential expression of one
allele over the other and contributes to adaptive phenotypic plasticity. Here, we used a …

In diploid mammals, allele-specific three-dimensional (3D) genome architecture may lead to
imbalanced gene expression. Through ultradeep in situ Hi-C sequencing of three …