From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo
D Andergassen, JL Rinn - Nature Reviews Genetics, 2022 - nature.com
Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …
(lncRNA) loci in the human genome, but evidence of functional significance has remained …
Modern epigenetics methods in biological research
Y Li - Methods, 2021 - Elsevier
The definition of epigenetics refers that molecular modifications on DNA that can regulate
gene activity are independent of DNA sequence and mitotically stable. Notably, epigenetics …
gene activity are independent of DNA sequence and mitotically stable. Notably, epigenetics …
Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression
D Andergassen, CP Dotter, D Wenzel, V Sigl… - elife, 2017 - elifesciences.org
To determine the dynamics of allelic-specific expression during mouse development, we
analyzed RNA-seq data from 23 F1 tissues from different developmental stages, including …
analyzed RNA-seq data from 23 F1 tissues from different developmental stages, including …
Insights into the biogenesis and potential functions of exonic circular RNA
Circular RNAs (circRNAs) exhibit unique properties due to their covalently closed nature.
Models of circRNAs synthesis and function are emerging but much remains undefined about …
Models of circRNAs synthesis and function are emerging but much remains undefined about …
[HTML][HTML] Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages
Genomic imprinting and X chromosome inactivation (XCI) require epigenetic mechanisms to
encode allele-specific expression, but how these specific tasks are accomplished at single …
encode allele-specific expression, but how these specific tasks are accomplished at single …
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3
In mammalian genomes, differentially methylated regions (DMRs) and histone marks
including trimethylation of histone 3 lysine 27 (H3K27me3) at imprinted genes are …
including trimethylation of histone 3 lysine 27 (H3K27me3) at imprinted genes are …
The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes
D Andergassen, M Muckenhuber, PC Bammer… - PLoS …, 2019 - journals.plos.org
Long non-coding (lnc) RNAs are numerous and found throughout the mammalian genome,
and many are thought to be involved in the regulation of gene expression. However, the …
and many are thought to be involved in the regulation of gene expression. However, the …
Cell-type specificity of genomic imprinting in cerebral cortex
In mammalian genomes, a subset of genes is regulated by genomic imprinting, resulting in
silencing of one parental allele. Imprinting is essential for cerebral cortex development, but …
silencing of one parental allele. Imprinting is essential for cerebral cortex development, but …
Allele-specific regulatory effects on the pig transcriptome
Y Lin, J Li, L Chen, J Bai, J Zhang, Y Wang, P Liu… - …, 2023 - academic.oup.com
Background Allele-specific expression (ASE) refers to the preferential expression of one
allele over the other and contributes to adaptive phenotypic plasticity. Here, we used a …
allele over the other and contributes to adaptive phenotypic plasticity. Here, we used a …
Haplotype-resolved 3D chromatin architecture of the hybrid pig
Y Lin, J Li, Y Gu, L Jin, J Bai, J Zhang, Y Wang… - Genome …, 2024 - genome.cshlp.org
In diploid mammals, allele-specific three-dimensional (3D) genome architecture may lead to
imbalanced gene expression. Through ultradeep in situ Hi-C sequencing of three …
imbalanced gene expression. Through ultradeep in situ Hi-C sequencing of three …