Viral vectors have been used for a broad spectrum of gene therapy for both acute and
chronic diseases. In the context of cancer gene therapy, viral vectors expressing anti-tumor …

Infectious etiology is implicated in chronic diseases such as gastric ulcer or atherosclerosis.
However,“infection” is a recent term in the field of obesity. Since the first report in 1982 of …

Viral vectors have been proven useful in a broad spectrum of gene therapy applications due
to their possibility to accommodate foreign genetic material for both local and systemic …

Background This study aims to investigate the molecular mechanism of Adenovirus type 36
(Ad36) in adipocyte differentiation and glucolipid metabolism. Methods Rat obesity model …

Abstract Human Adenoviruses (HAdV) are nearly ubiquitous pathogens comprising
numerous sub-types that infect various tissues and organs. Among many encoded proteins …

Type 2 diabetes mellitus (T2D), which is often accompanied by hyperinsulinemia and insulin
resistance, is associated with an increased risk for developing mild cognitive impairment …

Background Type 2 diabetes is often linked with impaired proximal insulin signaling. Hence,
a therapeutic agent that enhances cellular glucose uptake without requiring proximal insulin …

Impaired proximal insulin signaling is often present in diabetes. Hence, approaches to
enhance glucose disposal independent of proximal insulin signaling are desirable …

Background Obesity and type 2 diabetes (T2D) are closely associated with hepatic steatosis
(HS), which if untreated can advance to serious liver conditions. Since insulin promotes …

Objective Impaired glycemic control is a common comorbidity of obesity. E4orf1 (E4), an
adenovirus-derived protein, reduces the activity of insulin receptor substrate (IRS), yet …