The molecular heterogeneity of store-operated Ca2+ entry in vascular endothelial cells: the different roles of Orai1 and TRPC1/TRPC4 channels in the transition from …
F Moccia, V Brunetti, A Perna, G Guerra… - International journal of …, 2023 - mdpi.com
Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …
The emerging role of N-Methyl-D-Aspartate (NMDA) receptors in the cardiovascular system: Physiological implications, pathological consequences, and therapeutic …
T Soda, V Brunetti, R Berra-Romani… - International journal of …, 2023 - mdpi.com
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ion channels that are activated
by the neurotransmitter glutamate, mediate the slow component of excitatory …
by the neurotransmitter glutamate, mediate the slow component of excitatory …
Allyl Isothiocianate Induces Ca2+ Signals and Nitric Oxide Release by Inducing Reactive Oxygen Species Production in the Human Cerebrovascular Endothelial Cell …
R Berra-Romani, V Brunetti, G Pellavio, T Soda… - Cells, 2023 - mdpi.com
Nitric oxide (NO) represents a crucial mediator to regulate cerebral blood flow (CBF) in the
human brain both under basal conditions and in response to somatosensory stimulation. An …
human brain both under basal conditions and in response to somatosensory stimulation. An …
Target molecules of STIM proteins in the central nervous system
K Serwach, J Gruszczynska-Biegala - Frontiers in molecular …, 2020 - frontiersin.org
Stromal interaction molecules (STIMs), including STIM1 and STIM2, are single-pass
transmembrane proteins that are located predominantly in the endoplasmic reticulum (ER) …
transmembrane proteins that are located predominantly in the endoplasmic reticulum (ER) …
Endothelial TRPV1 as an emerging molecular target to promote therapeutic angiogenesis
Therapeutic angiogenesis represents an emerging strategy to treat ischemic diseases by
stimulating blood vessel growth to rescue local blood perfusion. Therefore, injured …
stimulating blood vessel growth to rescue local blood perfusion. Therefore, injured …
Therapeutic potential of endothelial colony-forming cells in ischemic disease: strategies to improve their regenerative efficacy
Cardiovascular disease (CVD) comprises a range of major clinical cardiac and circulatory
diseases, which produce immense health and economic burdens worldwide. Currently …
diseases, which produce immense health and economic burdens worldwide. Currently …
NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain …
The excitatory neurotransmitter glutamate gates post-synaptic N-methyl-d-aspartate (NMDA)
receptors (NMDARs) to mediate extracellular Ca 2+ entry and stimulate neuronal nitric oxide …
receptors (NMDARs) to mediate extracellular Ca 2+ entry and stimulate neuronal nitric oxide …
Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development
In-depth characterization of heart-brain communication in critically ill patients with severe
acute respiratory failure is attracting significant interest in the COronaVIrus Disease 19 …
acute respiratory failure is attracting significant interest in the COronaVIrus Disease 19 …
GABAA and GABAB Receptors Mediate GABA-Induced Intracellular Ca2+ Signals in Human Brain Microvascular Endothelial Cells
Numerous studies recently showed that the inhibitory neurotransmitter, γ-aminobutyric acid
(GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by …
(GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by …
Targeting endolysosomal two-pore channels to treat cardiovascular disorders in the novel COronaVIrus Disease 2019
Emerging evidence hints in favor of a life-threatening link between severe acute respiratory
syndrome coronavirus type 2 (SARS-CoV-2) and the cardiovascular system. SARS-CoV-2 …
syndrome coronavirus type 2 (SARS-CoV-2) and the cardiovascular system. SARS-CoV-2 …