Denisovans, a group of now extinct humans who lived in Eastern Eurasia in the Middle and
Late Pleistocene, were first identified from DNA sequences just over a decade ago. Only ten …

Our understanding of population history in deep time has been assisted by fitting admixture
graphs (AGs) to data: models that specify the ordering of population splits and mixtures …

Background Skin color is a well-recognized adaptive trait and has been studied extensively
in humans. Understanding the genetic basis of adaptation of skin color in various …

Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here,
we report that genes involved in various human cancers evolved rapidly in Tibetans and six …

Human genetic history in East Asia is poorly understood. To clarify population relationships,
we obtained genome-wide data from 26 ancient individuals from northern and southern East …

Summary Northern East Asia was inhabited by modern humans as early as 40 thousand
years ago (ka), as demonstrated by the Tianyuan individual. Using genome-wide data …

Using genome-wide data of 89 ancient individuals dated to 5100 to 100 years before the
present (BP) from 29 sites across the Tibetan Plateau, we found plateau-specific ancestry …

Genome sequences are known for two archaic hominins—Neanderthals and Denisovans—
which interbred with anatomically modern humans as they dispersed out of Africa. We …

Past human genetic diversity and migration between southern China and Southeast Asia
have not been well characterized, in part due to poor preservation of ancient DNA in hot and …

Present-day Tibetans have adapted both genetically and culturally to the high altitude
environment of the Tibetan Plateau, but fundamental questions about their origins remain …