Summary Introduction Matrix metalloproteinases (MMPs) and 'aggrecanase'a disintegrin
and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play …

The ADAMs family of transmembrane proteins belongs to the zinc protease superfamily.
Members of the family have a modular design, characterized by the presence of …

This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor
necrosis factor converting enzyme (TACE), ADAM-17 has been reported to be an …

The elastic fibre system has a principal role in the structure and function of various types of
organs that require elasticity, such as large arteries, lung and skin,. Although elastic fibres …

Fertilization calcium waves are introduced, and the evidence from which we can infer
general mechanisms of these waves is presented. The two main classes of hypotheses put …

Since the discovery of the first disintegrin protein from snake venom and the following
identification of a mammalian membrane-anchored metalloprotease-disintegrin implicated …

Activated platelets bind numerous adhesive and procoagulant proteins by receptor-
mediated processes. Although there is little evidence to suggest that these processes are …

Mice lacking syndecan-1 are viable, fertile and have morphologically normal skin, hair and
ocular surface epithelia. While studying the response of these mice to corneal epithelial and …

Endoglin (ENG) is a transmembrane glycoprotein expressed on endothelial cells that
functions as a co-receptor for several ligands of the transforming growth factor beta (TGF-β) …

Human endoglin is an RGD-containing transmembrane glycoprotein identified in vascular
endothelial cells. Although endoglin is essential for angiogenesis and its expression is up …