Elevated glycolysis remains a universal and primary character of cancer metabolism, which
deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) …

Pancreatic ductal adenocarcinoma is prone to distant metastasis and is expected to become
the second leading cause of cancer-related death. In an extremely nutrient-deficient and …

Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …

There are over 120 types of brain tumor and approximately 45% of primary brain tumors are
gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a …

Tumor cells possess a high metabolic plasticity, which drives them to switch on the
anaerobic glycolysis and lactate production when challenged by hypoxia. Among the …

ABSTRACT C-Myc overexpression is a common finding in pancreatic cancer and predicts
the aggressive behavior of cancer cells. It binds to the promoter of different genes, thereby …

Apoptosis is a programmed cell death that occurs due to the production of several catabolic
enzymes. During this process, several morphological and biochemical changes occur in …

One of the principal biochemical characteristics of malignant cells compared to normal cells
is a metabolic switch from oxidative phosphorylation to increased glycolysis, even under …

The energy metabolism of tumor cells is considered one of the hallmarks of cancer because
it is different from normal cells and mainly consists of aerobic glycolysis, fatty acid oxidation …

To sustain their high proliferation rates, most cancer cells rely on glycolytic metabolism, with
production of lactic acid. For many years, lactate was seen as a metabolic waste of glycolytic …