Pathogenesis of pneumonia and acute lung injury

ME Long, RK Mallampalli, JC Horowitz - Clinical Science, 2022 - portlandpress.com
Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary
and critical care healthcare professionals, and these challenges have recently garnered …

The gut-lung axis in health and respiratory diseases: a place for inter-organ and inter-kingdom crosstalks

R Enaud, R Prevel, E Ciarlo, F Beaufils… - Frontiers in cellular …, 2020 - frontiersin.org
The gut and lungs are anatomically distinct, but potential anatomic communications and
complex pathways involving their respective microbiota have reinforced the existence of a …

Definition, causes, pathogenesis, and consequences of chronic obstructive pulmonary disease exacerbations

AI Ritchie, JA Wedzicha - Clinics in chest medicine, 2020 - chestmed.theclinics.com
Acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) are episodes of
symptom worsening 1 that have significant adverse consequences for patients. 2 The …

Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions

Z Yan, B Chen, Y Yang, X Yi, M Wei… - Nature …, 2022 - nature.com
The mechanistic role of the airway microbiome in chronic obstructive pulmonary disease
(COPD) remains largely unexplored. We present a landscape of airway microbe–host …

Chronic obstructive pulmonary disease exacerbation fundamentals: diagnosis, treatment, prevention and disease impact

M MacLeod, A Papi, M Contoli, B Beghé, BR Celli… - …, 2021 - Wiley Online Library
In chronic obstructive pulmonary disease (COPD), exacerbations (ECOPD), characterized
by an acute deterioration in respiratory symptoms, are fundamental events impacting …

The lung microbiome: progress and promise

SA Whiteside, JE McGinniss… - The Journal of Clinical …, 2021 - Am Soc Clin Investig
The healthy lung was long thought of as sterile, but recent advances using molecular
sequencing approaches have detected bacteria at low levels. Healthy lung bacteria largely …

Proteobacteria: a common factor in human diseases

G Rizzatti, LR Lopetuso, G Gibiino… - BioMed research …, 2017 - Wiley Online Library
Microbiota represents the entire microbial community present in the gut host. It serves
several functions establishing a mutualistic relation with the host. Latest years have seen a …

From hairballs to hypotheses–biological insights from microbial networks

L Röttjers, K Faust - FEMS microbiology reviews, 2018 - academic.oup.com
Microbial networks are an increasingly popular tool to investigate microbial community
structure, as they integrate multiple types of information and may represent systems-level …

Functional effects of the microbiota in chronic respiratory disease

KF Budden, SD Shukla, SF Rehman… - The lancet Respiratory …, 2019 - thelancet.com
The composition of the lung microbiome is increasingly well characterised, with changes in
microbial diversity or abundance observed in association with several chronic respiratory …

Microbiome helper: a custom and streamlined workflow for microbiome research

AM Comeau, GM Douglas, MGI Langille - MSystems, 2017 - Am Soc Microbiol
Sequence-based approaches to study microbiomes, such as 16S rRNA gene sequencing
and metagenomics, are uncovering associations between microbial taxa and a myriad of …