Several lines of preclinical and clinical research have confirmed that chronic low-grade
inflammation of adipose tissue is mechanistically linked to metabolic disease and organ …

BACKGROUND Obesity is caused by an imbalance between energy intake, ie eating and
energy expenditure (EE). Severe obesity is more prevalent in women than men worldwide …

The distribution of adipose tissue in the body has wide-ranging and reproducible
associations with health and disease. Accumulation of adipose tissue in the upper body …

Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex,
genetic background, disease state, certain drugs and hormones, development, and aging …

Adipose tissue is a highly heterogeneous endocrine organ. The heterogeneity among
different anatomical depots stems from their intrinsic differences in cellular and physiological …

Obesity, defined as excess fat mass, increases risks for multiple metabolic diseases, such as
type 2 diabetes, cardiovascular disease and several types of cancer. Over and above fat …

Obesity, characterized by excessive adiposity, is a risk factor for many metabolic
pathologies, such as type 2 diabetes mellitus (T2DM). Numerous studies have shown that …

Abdominal (central) obesity strongly correlates with (hepatic) insulin resistance and type 2
diabetes. Among several hypotheses that have been formulated, the 'portal theory'proposes …

FAT/CD36 is a multifunctional glycoprotein that facilitates long-chain fatty acid (FA) uptake
by cardiomyocytes and adipocytes and uptake of oxidized low density lipoproteins (oxLDL) …

Context: Fat distribution differs in men and women, but in both sexes, a predominantly
gluteal-femoral compared with abdominal (central) fat distribution is associated with lower …