The mouse brain is the most extensively studied brain of all species. We performed an
exhaustive review of the literature to establish our current state of knowledge on cell …

Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …

This Perspective will examine the organization of intrastriatal circuitry, review recent findings
in this area, and discuss how the pattern of connectivity between striatal neurons might give …

Depression is a complex disorder that takes an enormous toll on individual health. As
affected individuals display a wide variation in their clinical symptoms, the precise neural …

Highlights•Homeostatic plasticity plays an important role in mitigating striatal
pathophysiology in the early stages of PD.•Aberrant dopamine-dependent synaptic plasticity …

The nucleus accumbens (NAc) is clearly implicated in reward processing and drug
addiction, as well as in numerous neurological and psychiatric disorders; nevertheless, the …

The striatum is densely innervated by mesencephalic dopaminergic neurons that modulate
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …

Background Attention-deficit/hyperactive disorder (ADHD) is a neurodevelopmental disorder
that commonly occurs in children with a prevalence ranging from 3.4 to 7.2%. It profoundly …

The dorsal striatum, the largest subcortical structure of the basal ganglia, is critical in
controlling motor, procedural, and reinforcement-based behaviors. Although in mammals the …

The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …