Antibody–drug conjugates: an emerging concept in cancer therapy
RVJ Chari, ML Miller… - Angewandte Chemie …, 2014 - Wiley Online Library
Traditional cancer chemotherapy is often accompanied by systemic toxicity to the patient.
Monoclonal antibodies against antigens on cancer cells offer an alternative tumor‐selective …
Monoclonal antibodies against antigens on cancer cells offer an alternative tumor‐selective …
Recent advances in the total synthesis of cyclopropane-containing natural products
DYK Chen, RH Pouwer, JA Richard - Chemical Society Reviews, 2012 - pubs.rsc.org
In this tutorial review, recent advances in the synthesis of cyclopropane-containing natural
products are discussed, highlighting the application of novel synthetic methodologies and …
products are discussed, highlighting the application of novel synthetic methodologies and …
A field guide to foldamers
The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …
Recent developments in indole ring synthesis—methodology and applications
GW Gribble - Journal of the Chemical Society, Perkin Transactions 1, 2000 - pubs.rsc.org
1 Introduction 2 Sigmatropic rearrangements 2.1 Fischer indole synthesis 2.1. 1
Methodology 2.1. 2 Applications 2.1. 3 Mechanism 2.2 Gassman indole synthesis 2.3 Bartoli …
Methodology 2.1. 2 Applications 2.1. 3 Mechanism 2.2 Gassman indole synthesis 2.3 Bartoli …
Biosynthesis and metabolism of cyclopropane rings in natural compounds
LA Wessjohann, W Brandt, T Thiemann - Chemical reviews, 2003 - ACS Publications
Cyclopropane subunits occur in many natural products of secondary metabolism. 1 The
majority of cyclopropane-containing natural compounds have been isolated from plants …
majority of cyclopropane-containing natural compounds have been isolated from plants …
Selective Catalytic Hydrogenation of Heteroarenes with N-Graphene-Modified Cobalt Nanoparticles (Co3O4–Co/NGr@α-Al2O3)
F Chen, AE Surkus, L He, MM Pohl… - Journal of the …, 2015 - ACS Publications
Cobalt oxide/cobalt-based nanoparticles featuring a core–shell structure and nitrogen-
doped graphene layers on alumina are obtained by pyrolysis of Co (OAc) 2/phenanthroline …
doped graphene layers on alumina are obtained by pyrolysis of Co (OAc) 2/phenanthroline …
Design, synthesis, and evaluation of linker-duocarmycin payloads: toward selection of HER2-targeting antibody–drug conjugate SYD985
RC Elgersma, RGE Coumans, T Huijbregts… - Molecular …, 2015 - ACS Publications
Antibody–drug conjugates (ADCs) that are currently on the market or in clinical trials are
predominantly based on two drug classes: auristatins and maytansinoids. Both are tubulin …
predominantly based on two drug classes: auristatins and maytansinoids. Both are tubulin …
Synthesis of cyclopropane containing natural products
WA Donaldson - Tetrahedron, 2001 - Elsevier
While the cyclopropane ring is a highly strained entity, it is nonetheless found in a wide
variety of naturally occurring compounds including terpenes, pheromones, fatty acid …
variety of naturally occurring compounds including terpenes, pheromones, fatty acid …
Recent advances in the asymmetric synthesis of pharmacology-relevant nitrogen heterocycles via stereoselective aza-Michael reactions
MG Vinogradov, OV Turova, SG Zlotin - Organic & Biomolecular …, 2019 - pubs.rsc.org
The prevalence of nitrogen containing heterocycles in natural products and pharmaceuticals
is a doubtless fact. In this review, recent applications of a stereoselective aza-Michael …
is a doubtless fact. In this review, recent applications of a stereoselective aza-Michael …
DNA minor groove binders as potential antitumor and antimicrobial agents
PG Baraldi, A Bovero, F Fruttarolo… - Medicinal research …, 2004 - Wiley Online Library
DNA minor groove binders constitute an important class of derivatives in anticancer therapy.
Some of these compounds form noncovalent complexes with DNA (eg, distamycin A …
Some of these compounds form noncovalent complexes with DNA (eg, distamycin A …