Parasites of the genus Plasmodium have a complex life cycle. They alternate between their
final mosquito host and their intermediate hosts. The parasite can be either extra-or …

Malaria remains a highly prevalent disease in more than 90 countries and accounts for at
least 1 million deaths every year. Plasmodium falciparum infection is often associated with a …

The mechanistic basis of hepatic dysfunction, a clinically significant complication in malaria,
remains largely obscure. Although oxidative stress and associated apoptosis trigger hepatic …

Background Plasmodium falciparum can cause a diffuse encephalopathy known as cerebral
malaria (CM), a major contributor to malaria associated mortality. Despite treatment …

Programmed cell death (apoptosis) is an important regulator of the host's response during
infection with a variety of intracellular protozoan parasites. Parasitic pathogens have …

Plasmodium falciparum malaria remains a major cause of mortality throughout the tropical
world. Haematological abnormalities are considered a hallmark of malaria, bearing an …

As the mortality rate of 20–30% for severe falciparum malaria under even the best clinical
conditions testifies, access to antimalarial drugs is not sufficient to prevent an appreciable …

Nearly all animal cells possess the capacity to undergo programmed cell death (apoptosis)
when stimulated by an appropriate trigger. Apoptosis is crucial for maintaining social order …

Background The genetic background of the cynomolgus macaque (Macaca fascicularis) is
made complex by the high genetic diversity, population structure, and gene introgression …

Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions
of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this …