Drug efflux pumps play a key role in drug resistance and also serve other functions in
bacteria. There has been a growing list of multidrug and drug-specific efflux pumps …

Organic cation transporters (OCTs) of the solute carrier family (SLC) 22 and multidrug and
toxin extrusion (MATE) transporters of the SLC47 family have been identified as uptake and …

The solute-carrier gene (SLC) superfamily encodes membrane-bound transporters. The
SLC superfamily comprises 55 gene families having at least 362 putatively functional protein …

As sessile organisms, plants constantly monitor environmental cues and respond
appropriately to modulate their growth and development. Membrane transporters act as …

Key message This review summarizes the recent updates in the area of transporters of plant
secondary metabolites, including their applied aspects in metabolic engineering of …

OBJECTIVE—Metformin, an oral glucose-lowering drug, is taken up in hepatocytes by the
organic cation transporter (OCT) 1 and in renal epithelium by OCT2. In these cells, the …

Xenobiotic and metabolite extrusion is an important process for the proper functions of cells
and their compartments, including acidic organelles. MATE (multidrug and toxic compound …

The renal organic cation transport system mediates the tubular secretion of cationic
compounds including drugs, toxins and endogenous metabolites into urine. It consists of a …

Multidrug transporters belonging to the multidrug and toxic compound extrusion (MATE)
family expel dissimilar lipophilic and cationic drugs across cell membranes by dissipating a …

Metformin is used as a probe for OCT2 mediated transport when investigating possible DDIs
with new chemical entities. The aim of the current study was to investigate the ability of …