Autophagy is best known for its role in organelle and protein turnover, cell quality control,
and metabolism. The autophagic machinery has, however, also adapted to enable protein …

Breast cancer is a heterogeneous disease consisting of different biological subtypes, with
differences in terms of incidence, response to diverse treatments, risk of disease …

Background Epidemiological and experimental evidence has linked chronic inflammation to
cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are …

Triple-negative breast cancer (TNBC), defined as loss of estrogen, progesterone, and Her2
receptors, is a subtype of highly aggressive breast cancer with worse prognosis and poor …

Introduction Osteoporosis is the most common bone disorder where the hyperactive
osteoclasts represent the leading role during the pathogenesis. Targeting hyperactive …

ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of
transmembrane proteases involved in the shedding of some cell membrane proteins and …

Autophagy is a catabolic process that targets its cargo for lysosomal degradation. In addition
to its function in maintaining tissue homeostasis, autophagy is recognized to play a context …

Excess body weight and obesity have become significant risk factors for cancer
development. During obesity, adipose tissue alters its biological function, deregulating the …

Autophagy can function as a survival mechanism for cancer cells and therefore, its inhibition
is currently being explored as a therapy for different cancer types. For breast cancer, triple …

Objective. Triple negative breast cancer (TNBC) is a kind of cancer that endangers the lives
of women all over the world in the 21st century. Heat shock protein member 8 (HSPA8) is the …