Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms
The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin
on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by …
on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by …
Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants
M Korenkov, M Zehner, H Cohen-Dvashi… - Immunity, 2023 - cell.com
Somatic hypermutation (SHM) drives affinity maturation and continues over months in SARS-
CoV-2-neutralizing antibodies (nAbs). However, several potent SARS-CoV-2 antibodies …
CoV-2-neutralizing antibodies (nAbs). However, several potent SARS-CoV-2 antibodies …
Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies
MC Metcalf, BM Janus, R Yin, R Wang… - Nature …, 2023 - nature.com
Hepatitis C virus (HCV) is a major global health burden as the leading causative agent of
chronic liver disease and hepatocellular carcinoma. While the main antigenic target for HCV …
chronic liver disease and hepatocellular carcinoma. While the main antigenic target for HCV …
From structural studies to HCV vaccine design
I Yechezkel, M Law, N Tzarum - Viruses, 2021 - mdpi.com
Hepatitis C virus (HCV) is a serious and growing public health problem despite recent
developments of antiviral therapeutics. To achieve global elimination of HCV, an effective …
developments of antiviral therapeutics. To achieve global elimination of HCV, an effective …
Antibody responses in hepatitis C infection
M Law - Cold Spring Harbor Perspectives in …, 2021 - perspectivesinmedicine.cshlp.org
Antibody responses in hepatitis C virus (HCV) have been a rather mysterious research topic
for many investigators working in the field. Chronic HCV infection is often associated with …
for many investigators working in the field. Chronic HCV infection is often associated with …
Flexibility and intrinsic disorder are conserved features of hepatitis C virus E2 glycoprotein
The glycoproteins of hepatitis C virus, E1E2, are unlike any other viral fusion machinery yet
described, and are the current focus of immunogen design in HCV vaccine development; …
described, and are the current focus of immunogen design in HCV vaccine development; …
Specific antibodies induced by immunization with hepatitis B virus-like particles carrying hepatitis C virus envelope glycoprotein 2 epitopes show differential …
Hepatitis C virus (HCV) infection with associated chronic liver diseases is a major health
problem worldwide. Here, we designed hepatitis B virus (HBV) small surface antigen …
problem worldwide. Here, we designed hepatitis B virus (HBV) small surface antigen …
Hepatitis C virus envelope glycoproteins: a balancing act of order and disorder
SA Yost, Y Wang, J Marcotrigiano - Frontiers in immunology, 2018 - frontiersin.org
Chronic hepatitis C virus infection often leads to liver cirrhosis and primary liver cancer. In
2015, an estimated 71 million people were living with chronic HCV. Although infection rates …
2015, an estimated 71 million people were living with chronic HCV. Although infection rates …
Induction of neutralizing antibodies against hepatitis C virus by a subviral particle-based DNA vaccine
K Yato, M Matsuda, N Watanabe, K Watashi, H Aizaki… - Antiviral Research, 2022 - Elsevier
Direct-acting antivirals (DAAs) have been introduced for the treatment of hepatitis C virus
(HCV); however, there is still no available vaccine for preventing HCV infection. We …
(HCV); however, there is still no available vaccine for preventing HCV infection. We …
Hepatitis C Virus E1E2 Structure, Diversity, and Implications for Vaccine Development
Hepatitis C virus (HCV) is a major medical health burden and the leading cause of chronic
liver disease and cancer worldwide. More than 58 million people are chronically infected …
liver disease and cancer worldwide. More than 58 million people are chronically infected …