Bioactive natural products from novel microbial sources

VL Challinor, HB Bode - Annals of the New York Academy of …, 2015 - Wiley Online Library
Despite the importance of microbial natural products for human health, only a few bacterial
genera have been mined for the new natural products needed to overcome the urgent threat …

The great potential of entomopathogenic bacteria Xenorhabdus and Photorhabdus for mosquito control: a review

WJ da Silva, HL Pilz-Júnior, R Heermann… - Parasites & vectors, 2020 - Springer
The control of insects of medical importance, such as Aedes aegypti and Aedes albopictus
are still the only effective way to prevent the transmission of diseases, such as dengue …

A Genus Definition for Bacteria and Archaea Based on a Standard Genome Relatedness Index

RA Barco, GM Garrity, JJ Scott, JP Amend, KH Nealson… - MBio, 2020 - Am Soc Microbiol
Genus assignment is fundamental in the characterization of microbes, yet there is currently
no unambiguous way to demarcate genera solely using standard genomic relatedness …

Small molecule perimeter defense in entomopathogenic bacteria

JM Crawford, C Portmann, X Zhang… - Proceedings of the …, 2012 - National Acad Sciences
Two Gram-negative insect pathogens, Xenorhabdus nematophila and Photorhabdus
luminescens, produce rhabduscin, an amidoglycosyl-and vinyl-isonitrile-functionalized …

Thirty years of slug control using the parasitic nematode Phasmarhabditis hermaphrodita and beyond

R Rae, L Sheehy… - Pest Management …, 2023 - Wiley Online Library
Several slug species are highly pestiferous and threaten global sustainable agriculture.
Current control methods rely heavily on metaldehyde pellets, which are often ineffective …

Antibiotics from neglected bacterial sources

SJ Pidot, S Coyne, F Kloss, C Hertweck - International Journal of Medical …, 2014 - Elsevier
The current crop of antibiotics in clinical use are either natural products or their derivatives.
However, the rise of a multitude of different antibiotic resistant human pathogens has meant …

How the insect pathogen bacteria Bacillus thuringiensis and Xenorhabdus/Photorhabdus occupy their hosts

C Nielsen-LeRoux, S Gaudriault, N Ramarao… - Current opinion in …, 2012 - Elsevier
Insects are the largest group of animals on earth. Like mammals, virus, fungi, bacteria and
parasites infect them. Several tissue barriers and defense mechanisms are common for …

Xenorhabdus spp.: An Overview of the Useful Facets of Mutualistic Bacteria of Entomopathogenic Nematodes

MMM Abd-Elgawad - Life, 2022 - mdpi.com
Mounting concern over the misuse of chemical pesticides has sparked broad interest for
safe and effective alternatives to control plant pests and pathogens. Xenorhabdus bacteria …

Antiprotozoal activity of different Xenorhabdus and Photorhabdus bacterial secondary metabolites and identification of bioactive compounds using the easyPACId …

SH Gulsen, E Tileklioglu, E Bode, H Cimen… - Scientific reports, 2022 - nature.com
Natural products have been proven to be important starting points for the development of
new drugs. Bacteria in the genera Photorhabdus and Xenorhabdus produce antimicrobial …

Evolution and taxonomy of nematode-associated entomopathogenic bacteria of the genera Xenorhabdus and Photorhabdus: an overview

E Sajnaga, W Kazimierczak - Symbiosis, 2020 - Springer
Entomopathogenic bacteria from the genera Photorhabdus and Xenorhabdus are closely
related Gram-negative bacilli from the family Enterobacteriaceae (γ-Proteobacteria). They …