Role of mammalian target of rapamycin in hypoxic or ischemic brain injury: potential neuroprotection and limitations
H Chen, Y Qu, B Tang, T Xiong, D Mu - Reviews in the …, 2012 - degruyter.com
Hypoxic or ischemic stress causes serious brain injury via various pathologic mechanisms
including suppressed protein synthesis, neuronal apoptosis, and the release of neurotoxic …
including suppressed protein synthesis, neuronal apoptosis, and the release of neurotoxic …
mTOR activates hypoxia-inducible factor-1α and inhibits neuronal apoptosis in the developing rat brain during the early phase after hypoxia–ischemia
H Chen, T Xiong, Y Qu, F Zhao, D Ferriero, D Mu - Neuroscience letters, 2012 - Elsevier
The mammalian target of rapamycin (mTOR) exerts neuroprotective effects under hypoxic or
ischemic conditions. To explore whether mTOR participates in neuroprotective signaling …
ischemic conditions. To explore whether mTOR participates in neuroprotective signaling …
[HTML][HTML] Estrogen-producing endometrioid adenocarcinoma resembling sex cord-stromal tumor of the ovary: a review of four postmenopausal cases
T Katoh, M Yasuda, K Hasegawa, E Kozawa… - Diagnostic …, 2012 - Springer
Abstract The 4 present cases with endometrioid adenocarcinoma (EMA) of the ovary were
characterized by estrogen overproduction and resemblance to sex cord-stromal tumor …
characterized by estrogen overproduction and resemblance to sex cord-stromal tumor …
[HTML][HTML] The proliferation, apoptosis, invasion of endothelial-like epithelial ovarian cancer cells induced by hypoxia
P Zhu, Y Ning, L Yao, M Chen, C Xu - Journal of Experimental & Clinical …, 2010 - Springer
Background Epithelial ovarian cancer is one of the most malignant cancers in women
because metastasis occurs in the most of patients by the time of diagnosis. Cancer cells …
because metastasis occurs in the most of patients by the time of diagnosis. Cancer cells …
[HTML][HTML] Transforming growth factor alpha (TGFα) regulates granulosa cell tumor (GCT) cell proliferation and migration through activation of multiple pathways
Granulosa cell tumors (GCTs) are the most common ovarian estrogen producing tumors,
leading to symptoms of excessive estrogen such as endometrial hyperplasia and …
leading to symptoms of excessive estrogen such as endometrial hyperplasia and …
Immunohistochemical study of VEGF expression in oral squamous cell carcinomas: correlation with the mTOR–HIF-1α pathway
T Naruse, G Kawasaki, S Yanamoto… - Anticancer …, 2011 - ar.iiarjournals.org
The aim of this study was to clarify the relationship between vascular endothelial growth
factor (VEGF) expression and clinicopathological factors in oral squamous cell carcinoma …
factor (VEGF) expression and clinicopathological factors in oral squamous cell carcinoma …
Activation of PI3K/mTOR signaling pathway contributes to induction of vascular endothelial growth factor by hCG in bovine developing luteal cells
Z Zhang, D Yu, D Yin, Z Wang - Animal reproduction science, 2011 - Elsevier
We recently reported that HIF-1α plays a critical role in the regulation of vascular endothelial
growth factor (VEGF) expression in the developing letual cells (LCs) and VEGF-dependent …
growth factor (VEGF) expression in the developing letual cells (LCs) and VEGF-dependent …
Activation of NF‐κB signaling pathway during HCG‐induced VEGF expression in luteal cells
Z Zhang, Y Huang, J Zhang, Z Liu, Q Lin… - Cell Biology …, 2019 - Wiley Online Library
Vascular endothelial growth factor (VEGF) plays an essential role in luteal angiogenesis, the
present study therefore utilized luteal cells cultured in vitro to further investigate the …
present study therefore utilized luteal cells cultured in vitro to further investigate the …
[HTML][HTML] Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5
JA MacDonald, N Kura, C Sussman… - Journal of ovarian …, 2018 - Springer
Background Cellular metabolic changes that accompany malignant transformation have
been heralded as hallmark features of cancer. However, metabolic signatures between …
been heralded as hallmark features of cancer. However, metabolic signatures between …
Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells
UM Haltia, N Andersson, B Yadav, A Färkkilä… - Gynecologic …, 2017 - Elsevier
Objective Resistance to standard chemotherapy poses a major clinical problem in the
treatment of ovarian cancer patients. Adult-type granulosa cell tumor (AGCT) is a unique …
treatment of ovarian cancer patients. Adult-type granulosa cell tumor (AGCT) is a unique …