The hepatitis B virus (HBV) is a small enveloped DNA virus, which primarily infects
hepatocytes and causes acute and persistent liver disease. Epidemiological studies have …

A growing body of literature highlights the cross-talk between tumor cells and the
surrounding peri-tumoral stroma as a key modulator of the processes of …

Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole …

Objective Sorafenib is the standard systemic therapy for advanced hepatocellular carcinoma
(HCC). Survival benefits of resection/local ablation for early HCC are compromised by 70 …

Chronic jet lag induces spontaneous hepatocellular carcinoma (HCC) in wild-type mice
following a mechanism very similar to that observed in obese humans. The process initiates …

Tumor-initiating cells (T-ICs) are a subpopulation of chemoresistant tumor cells that have
been shown to cause tumor recurrence upon chemotherapy. Identification of T-ICs and their …

Hepatocellular carcinoma (HCC) is one of the most frequent forms of liver cancer, and
effective treatment methods are limited due to tumor heterogeneity. There is a great need for …

Background & Aims In approximately 70% of patients with hepatocellular carcinoma (HCC)
treated by resection or ablation, disease recurs within 5 years. Although gene expression …

Current staging systems of cancer are mainly based on the anatomical extent of disease.
They need refinement by biological parameters to improve stratification of patients for tumor …

Objective The biological heterogeneity of hepatocellular carcinoma (HCC) makes prognosis
difficult. We translate the results of a genome-wide high-throughput analysis into a tool that …