Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …

Acyl-CoA: diacylglycerol acyltransferase (DGAT, EC 2.3. 1.20) catalyzes the last reaction in
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …

Lipid droplet (LD) functions are regulated by a complement of integral and peripheral
proteins that associate with the bounding LD phospholipid monolayer. Defining the …

Triglyceride (TG) storage in adipose tissue provides the major reservoir for metabolic energy
in mammals. During lipolysis, fatty acids (FAs) are hydrolyzed from adipocyte TG stores and …

Hepatic steatosis, the first step in the progression of nonalcoholic fatty liver disease, is
characterized by triglyceride accumulation in hepatocytes and is highly prevalent in people …

Lipid droplets (LDs) are ubiquitous, endoplasmic reticulum (ER)-derived organelles that
mediate the sequestration of neutral lipids (eg triacylglycerol and sterol esters), providing a …

Lipid droplets (LDs) are endoplasmic reticulum–derived organelles that consist of a core of
neutral lipids encircled by a phospholipid monolayer decorated with proteins. As hubs of …

The endoplasmic reticulum is the port of entry for proteins into the secretory pathway and the
site of synthesis for several important lipids, including cholesterol, triacylglycerol, and …

Triacylglycerols (TAG) serve as the predominant form of energy storage in mammalian cells,
and TAG synthesis influences conditions such as obesity, fatty liver, and insulin resistance …

Triacylglycerol (TAG) is the major storage lipid in most terrestrial plants and microalgae, and
has great nutritional and industrial value. Since the demand for vegetable oil is consistently …