Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies

KM Kennedy, MC de Goffau, ME Perez-Muñoz… - Nature, 2023 - nature.com
Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and
placenta) are stably colonized by microbial communities in a healthy pregnancy remains a …

The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis

N Gomez-Lopez, J Galaz, D Miller… - …, 2022 - rep.bioscientifica.com
In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

Fetal meconium does not have a detectable microbiota before birth

KM Kennedy, MJ Gerlach, T Adam, MM Heimesaat… - Nature …, 2021 - nature.com
Microbial colonization of the human intestine impacts host metabolism and immunity;
however, exactly when colonization occurs is unclear. Although many studies have reported …

Human milk oligosaccharides and bacterial profile modulate infant body composition during exclusive breastfeeding

AS Cheema, Z Gridneva, AJ Furst, AS Roman… - International Journal of …, 2022 - mdpi.com
Human milk is a complex and variable ecosystem fundamental to the development of
newborns. This study aimed to investigate relationships between human milk …

Exclusively breastfed infant microbiota develops over time and is associated with human milk oligosaccharide intakes

AS Cheema, ML Trevenen, BA Turlach… - International Journal of …, 2022 - mdpi.com
Temporal development of maternal and infant microbiomes during early life impacts short-
and long-term infant health. This study aimed to characterize bacterial dynamics within …

From intrauterine to extrauterine Life—The role of endogenous and exogenous factors in the regulation of the intestinal microbiota community and gut maturation in …

A Socha-Banasiak, M Pawłowska, E Czkwianianc… - Frontiers in …, 2021 - frontiersin.org
Differentiation of the digestive tube and formation of the gut unit as a whole, are regulated by
environmental factors through epigenetic modifications which enhance cellular plasticity …

Gut innervation and enteric nervous system development: a spatial, temporal and molecular tour de force

YN Kang, C Fung, P Vanden Berghe - Development, 2021 - journals.biologists.com
During embryonic development, the gut is innervated by intrinsic (enteric) and extrinsic
nerves. Focusing on mammalian ENS development, in this Review we highlight how …

From gut to placenta: understanding how the maternal microbiome models life-long conditions

J Ruiz-Triviño, D Álvarez, ÁP Cadavid J… - Frontiers in …, 2023 - frontiersin.org
The microbiome-defined as the microbiota (bacteria, archaea, lower and higher eukaryotes),
their genomes, and the surrounding environmental conditions-has a well-described range of …

Does the amniotic fluid of mice contain a viable microbiota?

AD Winters, R Romero, JM Greenberg, J Galaz… - Frontiers in …, 2022 - frontiersin.org
The existence of an amniotic fluid microbiota (ie, a viable microbial community) in mammals
is controversial. Its existence would require a fundamental reconsideration of fetal in utero …

A philosophical perspective on the prenatal in utero microbiome debate

J Walter, MW Hornef - Microbiome, 2021 - Springer
Within the last 6 years, a research field has emerged that focuses on the characterization of
microbial communities in the prenatal intrauterine environment of humans and their putative …