Innate immune receptors have a key role in immune surveillance by sensing
microorganisms and initiating protective immune responses. However, the innate immune …

Malaria is a major killer of children worldwide and the strongest known force for evolutionary
selection in the recent history of the human genome. The past decade has seen growing …

Malaria is a major cause of disease and death in tropical countries. A safe and effective
vaccine is essential to achieve significant and sustained reductions in malaria-related …

The type I interferon (IFN) 2 receptor (IFNAR) is comprised, as other cytokine receptors, of
multiple components, in this case designated IFNAR1 and IFNAR2. However it is unique …

Although Toll-like receptor 9 (TLR9) has been implicated in cytokine and type I interferon
(IFN) production during malaria in humans and mice, the high AT content of the Plasmodium …

IL-10 produced by CD4+ T cells suppresses inflammation by inhibiting T cell functions and
the upstream activities of antigen presenting cells (APCs). IL-10 was first identified in Th2 …

Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …

Neutrophils are the most abundant leukocyte population in the bloodstream, the primary
compartment of Plasmodium sp. infection. However, the role of these polymorphonuclear …

Type I interferons (IFNs) function as the first line of defense against viral infections by
modulating cell growth, establishing an antiviral state and influencing the activation of …

For a long time, the family of type I interferons (IFN‐α/β) has received little attention outside
the fields of virology and tumor immunology. In recent years, IFN‐α/β regained the interest of …