Red blood cell metabolism in vivo and in vitro

A D'Alessandro, AT Anastasiadi, VL Tzounakas… - Metabolites, 2023 - mdpi.com
Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …

The value of a complete blood count (CBC) for sepsis diagnosis and prognosis

L Agnello, RV Giglio, G Bivona, C Scazzone… - Diagnostics, 2021 - mdpi.com
Sepsis represents an important global health burden due to its high mortality and morbidity.
The rapid detection of sepsis is crucial in order to prevent adverse outcomes and reduce …

Neutrophil-to-lymphocyte ratio, past, present and future perspectives

R Zahorec - Bratisl Lek Listy, 2021 - search.ebscohost.com
In the review we analyzed short history of the establishment of a novel hematological
parameter for systemic inflammation and stress coined as a neutrophil to lymphocyte ratio …

DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia

LKM Lam, S Murphy, D Kokkinaki, A Venosa… - Science translational …, 2021 - science.org
Red blood cells (RBCs) are essential for aerobic respiration through delivery of oxygen to
distant tissues. However, RBCs are currently considered immunologically inert, and few, if …

Physiology and inflammation driven pathophysiology of iron homeostasis—mechanistic insights into anemia of inflammation and its treatment

L Lanser, D Fuchs, K Kurz, G Weiss - Nutrients, 2021 - mdpi.com
Anemia is very common in patients with inflammatory disorders. Its prevalence is associated
with severity of the underlying disease, and it negatively affects quality of life and cardio …

The evolving erythrocyte: red blood cells as modulators of innate immunity

HL Anderson, IE Brodsky… - The Journal of …, 2018 - journals.aai.org
The field of red cell biology is undergoing a quiet revolution. Long assumed to be inert
oxygen carriers, RBCs are emerging as important modulators of the innate immune …

A pairwise cytokine code explains the organism-wide response to sepsis

M Takahama, A Patil, G Richey, D Cipurko… - Nature …, 2024 - nature.com
Sepsis is a systemic response to infection with life-threatening consequences. Our
understanding of the molecular and cellular impact of sepsis across organs remains …

Impact of COVID‐19 on red blood cell rheology.

C Renoux, R Fort, E Nader, C Boisson… - British journal of …, 2021 - search.ebscohost.com
Abstract Keywords: COVID-19; red blood cell; deformability; aggregation; blood viscosity EN
COVID-19 red blood cell deformability aggregation blood viscosity e108 e111 4 02/17/21 …

Role of nitric oxide carried by hemoglobin in cardiovascular physiology: developments on a three-gas respiratory cycle

RT Premont, JD Reynolds, R Zhang… - Circulation …, 2020 - Am Heart Assoc
A continuous supply of oxygen is essential for the survival of multicellular organisms. The
understanding of how this supply is regulated in the microvasculature has evolved from …

Metabolic influences modulating erythrocyte deformability and eryptosis

JF Brun, E Varlet-Marie, J Myzia… - Metabolites, 2021 - mdpi.com
Many factors in the surrounding environment have been reported to influence erythrocyte
deformability. It is likely that some influences represent reversible changes in erythrocyte …