[HTML][HTML] Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

[HTML][HTML] Multi-Mechanistic Approaches to the Treatment of Traumatic Brain Injury: A Review

DG Lynch, RK Narayan, C Li - Journal of Clinical Medicine, 2023 - mdpi.com
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Despite
extensive research efforts, the majority of trialed monotherapies to date have failed to …

[HTML][HTML] Very delayed remote ischemic post-conditioning induces sustained neurological recovery by mechanisms involving enhanced angioneurogenesis and …

TR Doeppner, B Zechmeister, B Kaltwasser… - Frontiers in Cellular …, 2018 - frontiersin.org
Ischemic conditioning is defined as a transient and subcritical period of ischemia integrated
in an experimental paradigm that involves a stimulus of injurious ischemia, activating …

Delayed CO2 postconditioning promotes neurological recovery after cryogenic traumatic brain injury by downregulating IRF7 expression

Y Li, R Chen, GP Shen, J Yin, Y Li… - CNS Neuroscience …, 2023 - Wiley Online Library
Aims Few treatments are available in the subacute phase of traumatic brain injury (TBI)
except rehabilitation training. We previously reported that transient CO2 inhalation applied …

Remote ischemic conditioning reduced acute lung injury after traumatic brain injury in the mouse

M Saber, AD Rice, I Christie, RG Roberts, KS Knox… - Shock, 2021 - journals.lww.com
Traumatic brain injury (TBI) can induce acute lung injury (ALI). The exact pathomechanism
of TBI-induced ALI is poorly understood, limiting treatment options. Remote ischemic …

[HTML][HTML] Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury

RP Bruhns, MI Sulaiman, M Gaub, EH Bae… - Frontiers in Behavioral …, 2022 - frontiersin.org
Introduction: Traumatic brain injury (mTBI) is a leading cause of disability in the US.
Angiotensin 1-7, an endogenous peptide, acts at MAS receptors to inhibit inflammatory …

[HTML][HTML] The impact of serial remote ischemic conditioning on dynamic cerebral autoregulation and brain injury related biomarkers

Y Qu, P Zhang, QY He, YY Sun, MQ Wang… - Frontiers in …, 2022 - frontiersin.org
Objective Recent studies have demonstrated the positive roles of remote ischemic
conditioning (RIC) in patients with cerebrovascular diseases; however, the mechanisms …

Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI

KE Singer, TE Wallen, MC Morris… - Journal of Trauma …, 2021 - journals.lww.com
BACKGROUND Traumatic brain injury (TBI) is common in civilians and military personnel.
No potential therapeutics have been evaluated to prevent secondary injury induced by the …

Propranolol attenuates cognitive, learning, and memory deficits in a murine model of traumatic brain injury

M Zeeshan, M Hamidi, T O'Keeffe, EH Bae… - Journal of Trauma …, 2019 - journals.lww.com
BACKGROUND β-blockers have been shown to improve survival after traumatic brain injury
(TBI); however, the impact of continuous dosage of β-blockers on cognitive function has not …

Remote ischemic conditioning in emergency medicine—clinical frontiers and research opportunities

AFW Ho, J Chong, MEH Ong, DJ Hausenloy - Shock, 2020 - journals.lww.com
Time-critical acute ischemic conditions such as ST-elevation myocardial infarction and acute
ischemic stroke are staples in Emergency Medicine practice. While timely reperfusion …