Iron is an essential nutrient for both humans and pathogenic microbes. Because of its ability
to exist in one of two oxidation states, iron is an ideal redox catalyst for diverse cellular …

Drug-resistant bacteria pose a serious threat to human health worldwide. Current antibiotics
are losing efficacy and new antimicrobial agents are urgently needed. Living organisms are …

Iron is a versatile redox-active catalyst and a required cofactor within a diverse array of
biological processes. To almost all organisms, iron is both essential and potentially toxic …

Siderophores are biosynthetically produced and secreted by many bacteria, yeasts, fungi
and plants, to scavenge for ferric iron (Fe 3+). They are selective iron-chelators that have an …

The ability of bacteria to develop resistance to antimicrobial agents poses problems in the
treatment of numerous bacterial infections. One method to circumvent permeability-mediated …

Iron is an essential micronutrient for most life forms including the majority of resident bacteria
of the microbiota and their mammalian hosts. Bacteria have evolved numerous mechanisms …

Siderophores are secondary metabolites produced by different organisms in order to
scavenge iron from their surrounding environment making this essential element available …

Sideromycins are antibiotics covalently linked to siderophores. They are actively transported
into gram-positive and gram-negative bacteria. Energy-coupled transport across the outer …

Many antibiotics lack activity against Gram-negative bacteria because they cannot permeate
the outer membrane or suffer from efflux and, in the case of β-lactams, are degraded by β …

In order to address the dire need for new antibiotics to treat specific strains of drug resistant
Gram-negative bacterial infections, a mixed ligand analog of the natural Acinetobacter …