Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely
unexplored phenotype and development. We used single-cell RNA-seq to characterize …

Background Identifying differentially expressed genes (DEG) is a fundamental step in
studies that perform genome wide expression profiling. Typically, DEG are identified by …

It is widely understood that cancer is a significant cause of morbidity and mortality
worldwide. Despite numerous available treatments, prognosis for many remains poor, thus …

STAT3 is constitutively activated in many cancers and regulates gene expression to promote
cancer cell survival, proliferation, invasion, and migration. In diffuse large B cell lymphoma …

Primary central nervous system lymphomas (PCNSLs) are angiocentric neoplasia which
present dense monoclonal lymphocyte proliferation, and occur in brain parenchyma in 90 …

Small molecule activators could equally provide powerful tools as inhibitors do for
interrogating cellular signal transduction. However, targeted protein activation is chemically …

Janus kinases (JAKs) classically signal by activating STAT transcription factors but can also
regulate gene expression by epigenetically phosphorylating histone H3 on tyrosine 41 …

Background Gene profiling of diffuse large B cell lymphoma (DLBCL) has revealed broad
gene expression deregulation compared to normal B cells. While many studies have …

During innate immune responses, myeloid differentiation primary response 88 (MyD88)
functions as a critical signaling adaptor protein integrating stimuli from toll-like receptors …

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma, and front line
therapies have not improved overall outcomes since the advent of immunochemotherapy …