GSK-3: a multifaceted player in acute leukemias
AM Martelli, C Evangelisti, F Paganelli, F Chiarini… - Leukemia, 2021 - nature.com
Abstract Glycogen synthase kinase 3 (GSK-3) consists of two isoforms (α and β) that were
originally linked to glucose metabolism regulation. However, GSK-3 is also involved in …
originally linked to glucose metabolism regulation. However, GSK-3 is also involved in …
Tipping the scales with zebrafish to understand adaptive tumor immunity
KZ Miao, GY Kim, GK Meara, X Qin… - Frontiers in cell and …, 2021 - frontiersin.org
The future of improved immunotherapy against cancer depends on an in-depth
understanding of the dynamic interactions between the immune system and tumors. Over …
understanding of the dynamic interactions between the immune system and tumors. Over …
Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia
Relapse and refractory T-cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis,
and new combination therapies are sorely needed. Here, we used an ex vivo high …
and new combination therapies are sorely needed. Here, we used an ex vivo high …
PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes and
is largely driven by the NOTCH/MYC pathway. Yet, additional oncogenic drivers are …
is largely driven by the NOTCH/MYC pathway. Yet, additional oncogenic drivers are …
IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma
IRF4 is a master regulator of immunity and is also frequently overexpressed in mature
lymphoid neoplasms. Here, we demonstrate the oncogenicity of IRF4 in vivo, its potential …
lymphoid neoplasms. Here, we demonstrate the oncogenicity of IRF4 in vivo, its potential …
Generation of a Zebrafish Knock-In Model Recapitulating Childhood ETV6:: RUNX1-Positive B-Cell Precursor Acute Lymphoblastic Leukemia
Simple Summary Despite remarkable progress in the treatment of acute lymphoblastic
leukemia (ALL) in recent years, it remains a significant contributor to pediatric cancer-related …
leukemia (ALL) in recent years, it remains a significant contributor to pediatric cancer-related …
Dynamic Changes in Lymphocyte Populations Establish Zebrafish as a Thymic Involution Model
A Hasan, JJ Macias, B Wood… - The Journal of …, 2024 - journals.aai.org
The thymus is the site of T lymphocyte development and T cell education to recognize
foreign, but not self, Ags. B cells also reside and develop in the thymus, although their …
foreign, but not self, Ags. B cells also reside and develop in the thymus, although their …
[HTML][HTML] Zebrafish B cell acute lymphoblastic leukemia: new findings in an old model
Acute lymphoblastic leukemia (ALL) is the most common pediatric, and ninth most common
adult, cancer. ALL can develop in either B or T lymphocytes, but B-lineage ALL (B-ALL) …
adult, cancer. ALL can develop in either B or T lymphocytes, but B-lineage ALL (B-ALL) …
Zebrafish models of acute leukemias: Current models and future directions
B Molina, J Chavez, S Grainger - Wiley Interdisciplinary …, 2021 - Wiley Online Library
Acute myeloid leukemias (AML) and acute lymphoid leukemias (ALL) are heterogenous
diseases encompassing a wide array of genetic mutations with both loss and gain of …
diseases encompassing a wide array of genetic mutations with both loss and gain of …
Diverse Epithelial Lymphocytes in Zebrafish Revealed Using a Novel Scale Biopsy Method
Zebrafish are a compelling model to study lymphocytes because zebrafish and humans
have similar adaptive immune systems. Human and zebrafish lymphocyte types are …
have similar adaptive immune systems. Human and zebrafish lymphocyte types are …