[HTML][HTML] From actin waves to mechanism and back: how theory aids biological understanding
Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …
[HTML][HTML] Mechanochemical feedback loop drives persistent motion of liposomes
Achieving autonomous motion is a central objective in designing artificial cells that mimic
biological cells in form and function. Cellular motion often involves complex multiprotein …
biological cells in form and function. Cellular motion often involves complex multiprotein …
[HTML][HTML] Local actin dynamics couple speed and persistence in a cellular Potts model of cell migration
IMN Wortel, I Niculescu, PM Kolijn, NS Gov… - Biophysical journal, 2021 - cell.com
Cell migration is astoundingly diverse. Molecular signatures, cell-cell interactions, and
environmental structures each play their part in shaping cell motion, yielding numerous …
environmental structures each play their part in shaping cell motion, yielding numerous …
How cortical waves drive fission of motile cells
Cytokinesis—the division of a cell into two daughter cells—is a key step in cell growth and
proliferation. It typically occurs in synchrony with the cell cycle to ensure that a complete …
proliferation. It typically occurs in synchrony with the cell cycle to ensure that a complete …
[HTML][HTML] Actin-membrane release initiates cell protrusions
Despite the well-established role of actin polymerization as a driving mechanism for cell
protrusion, upregulated actin polymerization alone does not initiate protrusions. Using a …
protrusion, upregulated actin polymerization alone does not initiate protrusions. Using a …
[HTML][HTML] Computable early Caenorhabditis elegans embryo with a phase field model
X Kuang, G Guan, MK Wong, LY Chan… - PLOS Computational …, 2022 - journals.plos.org
Morphogenesis is a precise and robust dynamic process during metazoan embryogenesis,
consisting of both cell proliferation and cell migration. Despite the fact that much is known …
consisting of both cell proliferation and cell migration. Despite the fact that much is known …
Versatile patterns in the actin cortex of motile cells: Self-organized pulses can coexist with macropinocytic ring-shaped waves
A Yochelis, S Flemming, C Beta - Physical Review Letters, 2022 - APS
Self-organized patterns in the actin cytoskeleton are essential for eukaryotic cellular life.
They are the building blocks of many functional structures that often operate simultaneously …
They are the building blocks of many functional structures that often operate simultaneously …
[HTML][HTML] Delineating the mechanisms and design principles of Caenorhabditis elegans embryogenesis using in toto high-resolution imaging data and computational …
The nematode (roundworm) Caenorhabditis elegans is one of the most popular animal
models for the study of developmental biology, as its invariant development and transparent …
models for the study of developmental biology, as its invariant development and transparent …
[HTML][HTML] Comparative mapping of crawling-cell morphodynamics in deep learning-based feature space
Navigation of fast migrating cells such as amoeba Dictyostelium and immune cells are tightly
associated with their morphologies that range from steady polarized forms that support high …
associated with their morphologies that range from steady polarized forms that support high …
[HTML][HTML] Spontaneous transitions between amoeboid and keratocyte-like modes of migration
T Moldenhawer, E Moreno, D Schindler… - Frontiers in Cell and …, 2022 - frontiersin.org
The motility of adherent eukaryotic cells is driven by the dynamics of the actin cytoskeleton.
Despite the common force-generating actin machinery, different cell types often show …
Despite the common force-generating actin machinery, different cell types often show …