Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

White adipocytes store excess energy in the form of triglycerides, whereas brown and beige
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …

The relation between gut microbiota and the host has been suggested to benefit metabolic
homeostasis. Brown adipose tissue (BAT) and beige adipocytes facilitate thermogenesis to …

Histone deacetylase (HDAC) inhibitors are powerful epigenetic regulators that have
enormous therapeutic potential and have pleiotropic effects at the cellular and systemic …

Adipose tissue plays a central role in regulating whole-body energy and glucose
homeostasis through its subtle functions at both organ and systemic levels. On one hand …

Acetyl-CoA is a key intermediate situated at the intersection of many metabolic pathways.
The reliance of histone acetylation on acetyl-CoA enables the coordination of gene …

Brown and beige adipocytes arise from distinct developmental origins. Brown adipose tissue
(BAT) develops embryonically from precursors that also give to skeletal muscle. Beige fat …

Abstract Background Long non-coding RNAs (lncRNAs) are implicated in the development
of multiple cancers. In our previous study, we demonstrated that HDAC1/4-mediated …

Aortic dissection (AD) presents a medical challenge for clinicians. Here, to determine the
role of a novel small non-coding piRNA-823 (piR-823) in AD, murine and human aorta from …

Despite great strides being achieved in improving cancer patients' outcomes through better
therapies and combinatorial treatment, several hurdles still remain due to therapy …