The mechanical properties of cells are important in tissue homeostasis and enable cell
growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties …

During the establishment of neural circuitry axons often need to cover long distances to
reach remote targets. The stereotyped navigation of these axons defines the connectivity …

Regulation of the microtubule cytoskeleton is crucial for the development and maintenance
of neuronal architecture, and recent studies have highlighted the significance of regulated …

Neurons are vulnerable to physical insults, which compromise the integrity of both dendrites
and axons. Although several molecular pathways of axon regeneration are identified, our …

Kinesin superfamily proteins are microtubule-based molecular motors driven by the energy
of ATP hydrolysis. Among them, the kinesin-4 family is a unique motor that inhibits …

The neuronal microtubule cytoskeleton is key to establish axon-dendrite polarity. Dendrites
are characterized by the presence of minus-end out microtubules. However, the …

The polarized nature of neurons depends on their microtubule dynamics and orientation
determined by both microtubule-stabilizing and destabilizing factors. The role of …

Microtubules in neurons can be characterized based on their dynamic behavior (dynamic vs.
stable), on their point of origin (centrosomal vs. acentrosomal), on their relative orientation …

1Department of Biomedical Engineering, University of Mississippi, University, MS, USA,
2Department of Chemistry and Biochemistry, University of Mississippi, University, MS, USA …

Tubulin posttranslational modifications (PTMs) modulate the dynamic properties of
microtubules and their interactions with other proteins. However, the effects of tubulin PTMs …