Context: Acetaminophen overdose is regarded to a common cause of acute liver failure. The
hepatotoxicity leads to mitochondrial oxidative stress and subsequent necrotic …

Objective: To study the effect of metformin on amelioration of hepatotoxicity induced by
methotrexate. Materials and Methods: After a 2-weeks of acclimatization period, the animals …

Induction of oxidative stress events has been shown to be associated with lithium (Li)
hypothyroidism induction. Metformin (MET) is a commonly used antidiabetic drug with …

Thioacetamide (TAA) is a well known hepatototoxic chemical that is used to induce liver
cirrhosis similar to that occurred in human. This study was performed to investigate the …

Drug-induced hepatotoxicity is a significant cause of morbidity and is the major reason for
withdrawal of therapeutic drugs from the commercial market. The objective of the existing …

Methotrexate (MTX) is a folic acid antagonist, which is widely used as a cytotoxic
chemotherapeutic agent for malignancies as well as for the treatment of psoriasis, rheumatic …

The present study was taken up to evaluate the pathomorphological, biochemical and
molecular changes in methotrexate induced hepatotoxicity and it's amelioration by …

Objective: Recent literature demonstrated the ability of mesenchymal stem cells (MSCs) in
repairing injured liver, lung, or heart through several complicated mechanisms as …

Cyclodextrins (CDs) are cyclic oligosaccharides, which have recently been recognized as
useful excipients in different fields. Cyclodextrin (CD) can form water-soluble complexes with …