Nanoparticle protein corona: from structure and function to therapeutic targeting

G Bashiri, MS Padilla, KL Swingle, SJ Shepherd… - Lab on a Chip, 2023 - pubs.rsc.org
Nanoparticle (NP)-based therapeutics have ushered in a new era in translational medicine.
However, despite the clinical success of NP technology, it is not well-understood how NPs …

Modulating the toxicity of engineered nanoparticles by controlling protein corona formation: Recent advances and future prospects

J Wang, Y Xu, Y Zhou, J Zhang, J Jia, P Jiao… - Science of The Total …, 2023 - Elsevier
With the rapid development and widespread application of engineered nanoparticles
(ENPs), understanding the fundamental interactions between ENPs and biological systems …

Multi-scale modeling of folic acid-functionalized TiO 2 nanoparticles for active targeting of tumor cells

E Donadoni, P Siani, G Frigerio, C Di Valentin - Nanoscale, 2022 - pubs.rsc.org
Strategies based on the active targeting of tumor cells are emerging as smart and efficient
nanomedical procedures. Folic acid (FA) is a vitamin and a well-established tumor targeting …

Molecular dynamics simulations of cRGD-conjugated PEGylated TiO2 nanoparticles for targeted photodynamic therapy

P Siani, G Frigerio, E Donadoni… - Journal of Colloid and …, 2022 - Elsevier
The conjugation of high-affinity cRGD-containing peptides is a promising approach in
nanomedicine to efficiently reduce off-targeting effects and enhance the cellular uptake by …

Molecular Dynamics for the Optimal Design of Functionalized Nanodevices to Target Folate Receptors on Tumor Cells

E Donadoni, G Frigerio, P Siani, S Motta… - ACS Biomaterials …, 2023 - ACS Publications
Atomistic details on the mechanism of targeting activity by biomedical nanodevices of
specific receptors are still scarce in the literature, where mostly ligand/receptor pairs are …

Mechanism of RGD-conjugated nanodevice binding to its target protein integrin α V β 3 by atomistic molecular dynamics and machine learning

G Frigerio, E Donadoni, P Siani, J Vertemara, S Motta… - Nanoscale, 2024 - pubs.rsc.org
Active targeting strategies have been proposed to enhance the selective uptake of
nanoparticles (NPs) by diseased cells, and recent experimental findings have proven the …

Chemotherapeutics-Loaded Poly (Dopamine) Core-Shell Nanoparticles for Breast Cancer Treatment

M Steeves, D Combita, W Whelan, M Ahmed - Journal of Pharmacology and …, 2024 - ASPET
Chemophotothermal therapy is an emerging treatment of metastatic and drug-resistant
cancer anomalies. Among various photothermal agents tested, poly (dopamine) provides an …

Preparation of modified chitosan-based nano-TiO2–nisin composite packaging film and preservation mechanism applied to chilled pork

R Yan, M Liu, X Zeng, Q Du, Z Wu, Y Guo, M Tu… - International Journal of …, 2024 - Elsevier
Here, we developed a nano-TiO 2–nisin-modified chitosan composite packaging film and
investigated its properties and antibacterial activity, as well as its effect on chilled pork …

The effect of polymer coating on nanoparticles' interaction with lipid membranes studied by coarse-grained molecular dynamics simulations

E Donadoni, P Siani, G Frigerio, C Milani, Q Cui… - Nanoscale, 2024 - pubs.rsc.org
Nanoparticles'(NPs) permeation through cell membranes, whether it happens via passive or
active transport, is an essential initial step for their cellular internalization. The NPs' surface …

[HTML][HTML] Nature of TiO2–oligonucleotides interactions by atomistic molecular dynamics simulations

FA Soria, P Siani, C Di Valentin - Surfaces and Interfaces, 2024 - Elsevier
We used molecular dynamics simulations to investigate the adsorption behavior of single-
stranded deoxyribonucleic acid (ssDNA) segments on the anatase (101) surface. Four …