Highlights•APE1 protein repairs small base lesions in the DNA base excision repair
pathway.•APE1 converts oxidized inactive transcription factors to a reduced and active …

Cancer cachexia is a complex multifactorial syndrome marked by a continuous depletion of
skeletal muscle mass associated, in some cases, with a reduction in fat mass. It is …

STAT3 is an important transcription factor that regulates cell growth and proliferation by
regulating gene transcription of a plethora of genes. This protein also has many roles in …

Nowadays, molecular research is essential for the better understanding of tumor cells'
pathophysiology. The increasing number of neoplasms is taken under 'the molecular …

Essential oils (EOs) and their components have been reported to possess anticancer
properties and to increase the sensitivity of cancer cells to chemotherapy. The aim of this …

Signal transducer and activator of transcription 3 (STAT3) functions as a major molecular
switch that plays an important role in the communication between cytokines and kinases. In …

While a protein primary structure is determined by genetic code, its specific functional form is
mostly achieved in a dynamic interplay that includes actions of many enzymes involved in …

The protein disulfide isomerase A3 (PDIA3) is directly or indirectly involved in various
physiopathological processes and participates in cancer initiation, progression and …

Aim. This study aimed to learn the antineoplastic activity of curcumol (Cur) on prostate
cancer (PCa) and elucidate its potential molecular mechanism. Methods. The proliferation …

Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of
different regulatory pathways. STAT3 protein mediates some of these pathways and its …