Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. Sepsis can induce acute kidney injury and multiple organ failures …

B cell subsets differ in development, tissue distribution, and mechanisms of activation. In
response to infections, however, all can differentiate into extrafollicular plasmablasts that …

Background Sepsis is a life-threatening disease syndrome caused by a dysregulated host
response to infection and injury. Extracellular cold-inducible RNA-binding protein (eCIRP) …

Background Sepsis morbidity and mortality are aggravated by acute lung injury (ALI) or
acute respiratory distress syndrome (ARDS). Mouse B-1a cells are a phenotypically and …

Extracellular cold-inducible RNA-binding protein (eCIRP) is a recently discovered damage-
associated molecular pattern. Understanding the precise mechanism by which it …

Highlights•Unique developmental paths generate self-reactive B-1 constraint in BCR
responses.•Extensive repertoire shaping of B-1 cells for months after birth.•Accumulating …

Dysregulated immune profiles have been described in symptomatic patients infected with
SARS-CoV-2. Whether the reported immune alterations are specific to SARS-CoV-2 …

Sepsis is a life-threatening syndrome caused by anomalous host response to infection. The
pathogenesis of sepsis is complex, and immune dysfunction is the central link in its …

Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular
pattern (DAMP). Intercellular adhesion molecule-1 (ICAM-1) expressing neutrophils produce …

Although the abilities of the omentum to alleviate inflammation and prevent infection have
been revealed over the past decades, the underlying mechanisms remain largely …