Design, synthesis, and biological evaluation of thiazolidine‐2, 4‐dione conjugates as PPAR‐γ agonists
A library of synthesized conjugates of phenoxy acetic acid and thiazolidinedione 5a–m
showed potent peroxisome proliferator activated receptor‐γ (PPAR‐γ) transactivation as well …
showed potent peroxisome proliferator activated receptor‐γ (PPAR‐γ) transactivation as well …
To Probe Full and Partial Activation of Human Peroxisome Proliferator‐Activated Receptors by Pan‐Agonist Chiglitazar Using Molecular Dynamics Simulations
HJ Sullivan, X Wang, S Nogle, S Liao, C Wu - PPAR research, 2020 - Wiley Online Library
Chiglitazar is a promising new‐generation insulin sensitizer with low reverse effects for the
treatment of type II diabetes mellitus (T2DM) and has shown activity as a nonselective pan …
treatment of type II diabetes mellitus (T2DM) and has shown activity as a nonselective pan …
Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands
SN Lewis, Z Garcia, R Hontecillas… - Journal of computer …, 2015 - Springer
Peroxisome proliferator-activated receptor-gamma (PPARγ) is a nuclear hormone receptor
involved in regulating various metabolic and immune processes. The PPAR family of …
involved in regulating various metabolic and immune processes. The PPAR family of …
Identification of novel HIV 1-protease inhibitors: application of ligand and structure based pharmacophore mapping and virtual screening
A combined ligand and structure-based drug design approach provides a synergistic
advantage over either methods performed individually. Present work bestows a good …
advantage over either methods performed individually. Present work bestows a good …
Ligand-based drug design studies using predictive pharmacophore model generation on 4H-1,2,4-triazoles as AT1 receptor antagonists
Angiotensin II subtype I receptor constitutes a successful target for the treatment of
hypertension and cardiovascular diseases. In this study, the pharmacophore search was …
hypertension and cardiovascular diseases. In this study, the pharmacophore search was …
Discovery of a potent broad spectrum antimicrobial agent through pharmacophore modeling, virtual screening, in vitro antimicrobial evaluation and gastrointestinal …
In view of the role of DHFR in design and development of antimicrobials, we have attempted
to develop a rigorously validated structure-based pharmacophore model comprising of two …
to develop a rigorously validated structure-based pharmacophore model comprising of two …
AchE-OGT dual inhibitors: Potential Partners in Handling Alzheimer's Disease
M Sharma, AK Jainarayanan - bioRxiv, 2018 - biorxiv.org
The emerging role of O-GlcNAc Transferase (OGT) and tau protein in Alzheimer's disease
(AD) holds promises for the treatment of this life-threatening neurodegenerative disorder. In …
(AD) holds promises for the treatment of this life-threatening neurodegenerative disorder. In …
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PAR by Pan-Agonist - 2020 - pdfs.semanticscholar.org
Chiglitazar is a promising new-generation insulin sensitizer with low reverse effects for the
treatment of type II diabetes mellitus (T2DM) and has shown activity as a nonselective pan …
treatment of type II diabetes mellitus (T2DM) and has shown activity as a nonselective pan …
Refinement of the Docking Component of Virtual Screening for PPAR
SN Lewis - 2013 - vtechworks.lib.vt.edu
Exploration of peroxisome proliferator-activated receptor-gamma (PPAR") as a drug target
holds applications for treating a wide variety of chronic inflammation-related diseases. Type …
holds applications for treating a wide variety of chronic inflammation-related diseases. Type …
Refinement of the Docking Component of Virtual Screening for PPARγ Therapeutics Using Pharmacophore Analysis and Molecular Dynamics
SN Lewis - 2013 - search.proquest.com
Exploration of peroxisome proliferator-activated receptor-gamma (PPARγ) as a drug target
holds applications for treating a wide variety of chronic inflammation-related diseases. Type …
holds applications for treating a wide variety of chronic inflammation-related diseases. Type …