The neuroepigenome: implications of chemical and physical modifications of genomic DNA in schizophrenia
Schizophrenia is a chronic mental illness with a substantial genetic component. To unfold
the complex etiology of schizophrenia, it is important to understand the interplay between …
the complex etiology of schizophrenia, it is important to understand the interplay between …
Fundamental insights into the correlation between chromosome configuration and transcription
Eukaryotic chromosomes exhibit a hierarchical organization that spans a spectrum of length
scales, ranging from sub-regions known as loops, which typically comprise hundreds of …
scales, ranging from sub-regions known as loops, which typically comprise hundreds of …
Extensive long-range polycomb interactions and weak compartmentalization are hallmarks of human neuronal 3D genome
IA Pletenev, M Bazarevich, DR Zagirova… - Nucleic Acids …, 2024 - academic.oup.com
Chromatin architecture regulates gene expression and shapes cellular identity, particularly
in neuronal cells. Specifically, polycomb group (PcG) proteins enable establishment and …
in neuronal cells. Specifically, polycomb group (PcG) proteins enable establishment and …
Transcriptome and chromatin accessibility landscapes across 25 distinct human brain regions expand the susceptibility gene set for neuropsychiatric disorders
Brain region-and cell-specific transcriptomic and epigenomic molecular features are
associated with heritability for neuropsychiatric traits, but a systematic view, considering …
associated with heritability for neuropsychiatric traits, but a systematic view, considering …